Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA.
Nat Rev Immunol. 2012 Sep;12(9):663-9. doi: 10.1038/nri3280. Epub 2012 Aug 20.
Interactions between the central nervous system and the immune system have been studied primarily in the context of pathology, popularizing the view that interplay between these two systems is inherently detrimental. However, recent experimental data have demonstrated productive neuroimmune interactions that occur under normal physiological conditions. In this Essay, we outline our current understanding of contemporary neuroimmunology, describe a working model of T cell function in support of learning and memory, and offer ideas regarding the selective advantages of immune-mediated effects on brain function.
中枢神经系统与免疫系统之间的相互作用主要是在病理学的背景下进行研究的，这使得人们普遍认为这两个系统之间的相互作用本质上是有害的。然而，最近的实验数据表明，在正常生理条件下也会发生有益的神经免疫相互作用。在这篇文章中，我们概述了我们对当代神经免疫学的理解，描述了一个支持学习和记忆的 T 细胞功能的工作模型，并提出了关于免疫介导对大脑功能的影响具有选择性优势的观点。
