Nishio Jun, Isayama Teruto, Yoshimura Ichiro, Ohjimi Hiroyuki, Iwasaki Hiroshi, Naito Masatoshi
Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan.
J Foot Ankle Surg. 2012 Jan-Feb;51(1):76-9. doi: 10.1053/j.jfas.2011.09.005. Epub 2011 Oct 21.
Myxoid liposarcoma occurs predominantly in the deep soft tissues of the extremities, and tends to metastasize to a wide range of soft tissue or bone locations. We report a case of myxoid liposarcoma arising in the ankle of a 19-year-old man. A diagnosis of myxoid liposarcoma was made by open biopsy, and a wide resection requiring plastic surgical reconstruction was performed. Cytogenetic analysis of the resected tumor exhibited a reciprocal translocation t(12;16)(q13;p11) as the sole anomaly, which is found in more than 90% of myxoid liposarcoma cases. The patient had no evidence of local recurrence or metastasis within 7 years of follow-up. Although myxoid liposarcoma is rare in the ankle, it should be considered in the differential diagnosis of a painless soft tissue mass in this region.
黏液样脂肪肉瘤主要发生于四肢深部软组织，且易于转移至多种软组织或骨部位。我们报告1例发生于一名19岁男性踝关节的黏液样脂肪肉瘤病例。通过切开活检确诊为黏液样脂肪肉瘤，并进行了需要整形外科重建的广泛切除。对切除肿瘤的细胞遗传学分析显示，唯一的异常为相互易位t(12;16)(q13;p11)，在90%以上的黏液样脂肪肉瘤病例中均可发现。该患者在随访7年内无局部复发或转移迹象。尽管黏液样脂肪肉瘤在踝关节罕见，但在该区域无痛性软组织肿块的鉴别诊断中应予以考虑。
