Sección de Neurología, Hospital do Meixoeiro (CHUVI), Vigo, Pontevedra, Spain.
Neurologia. 2012 Sep;27(7):387-93. doi: 10.1016/j.nrl.2011.07.011. Epub 2011 Oct 22.
Lobar intracerebral haemorrhage (LIH), is a rare cause of stroke which accounts for about 20% of primary intracerebral haemorrhages. The most common causes are cerebral amyloid angiopathy (CAA), high blood pressure and others, such as using anti-platelet or anticoagulation agents. We analysed a series of patients with LIH and compared it with subgroups of patients with LIH who were previously receiving anti-platelet or anticoagulation agents. We determined the volume of the bleeding and its predictive value for mortality.
We consecutively and retrospectively included 162 patients diagnosed with LIH and cared for in the Neurology Department of Hospital Meixoeiro in Vigo between 1991 and 2009. We collected demographic characteristics, risk factors, aetiologies and symptoms, and conducted a comparative analysis between the general series and the subgroups of patients receiving anticoagulation and anti-platelet agents.
In the general series, the most common cause was possible or probable CAA followed by hypertension. In the subgroup of patients receiving anti-platelet or anticoagulation agents there were no differences in the variables studied, except for the frequency of heart disease. Nonetheless, there were differences with respect to age, heart disease and bleeding volume between the general series (patients not treated with anti-platelet or anticoagulation agents) when compared with the subgroups of patients receiving anti-platelet and anticoagulation agents.
We provide new information regarding the clinical behaviour of LIH and its differences in patients receiving anti-platelet or anticoagulation agents. Mortality is higher in cases of LIH on anticoagulants. LIH. Female sex and the volume of bleeding are predictors of mortality.
脑叶内出血（LIH）是一种罕见的中风病因，占原发性脑内出血的约 20%。最常见的病因是脑淀粉样血管病（CAA）、高血压和其他原因，如使用抗血小板或抗凝药物。我们分析了一系列 LIH 患者，并将其与先前接受抗血小板或抗凝药物治疗的 LIH 患者亚组进行比较。我们确定了出血量及其对死亡率的预测价值。
我们连续回顾性地纳入了 1991 年至 2009 年期间在维哥梅西欧罗医院神经内科就诊的 162 名诊断为 LIH 的患者。我们收集了人口统计学特征、危险因素、病因和症状，并对一般系列和接受抗凝和抗血小板药物治疗的亚组患者进行了比较分析。
在一般系列中，最常见的病因是可能或可能的 CAA，其次是高血压。在接受抗血小板或抗凝药物治疗的亚组患者中，除了心脏病的发生率外，研究变量没有差异。然而，与未接受抗血小板或抗凝药物治疗的一般系列患者（即未接受抗血小板或抗凝药物治疗的患者）相比，年龄、心脏病和出血量在一般系列和接受抗血小板和抗凝药物治疗的亚组患者之间存在差异。
我们提供了关于 LIH 临床行为及其在接受抗血小板或抗凝药物治疗的患者中的差异的新信息。抗凝治疗的 LIH 患者死亡率更高。女性性别和出血量是死亡率的预测因素。
