Department of Medicine, Wilford Hall Medical Center, Lackland Air Force Base, TX 78236, USA.
Diagn Microbiol Infect Dis. 2011 Dec;71(4):366-9. doi: 10.1016/j.diagmicrobio.2011.08.018. Epub 2011 Oct 21.
Leptospirosis is a widespread zoonotic infection characterized by acute febrile illness. Severely ill patients may require empiric treatment with broad-spectrum antibiotics prior to definitive diagnosis. We evaluated the efficacy of minocycline and tigecycline against leptospirosis in a hamster model. Hamsters were treated with either minocycline (5, 10, or 25 mg/kg per day) or tigecycline (5, 10, or 25 mg/kg per day) for 5 days. Controls included untreated animals and doxycycline-treated animals (5 mg/kg per day). Nine days after infection, all untreated animals were dead. All treated hamsters survived to the end of study (day 21). Study groups showed significantly improved survival compared to the untreated group (P < .01). Minocycline and tigecycline showed survival benefit comparable to the standard treatment, doxycycline. In the absence of doxycycline, minocycline may be considered as an alternative, while tigecycline may be useful in the management of severely ill patients prior to a definitive diagnosis.
钩端螺旋体病是一种广泛流行的人畜共患感染病，以急性发热性疾病为特征。严重感染的患者可能需要在明确诊断之前进行经验性的广谱抗生素治疗。我们在仓鼠模型中评估了米诺环素和替加环素对钩端螺旋体病的疗效。仓鼠接受米诺环素（5、10 或 25 mg/kg/天）或替加环素（5、10 或 25 mg/kg/天）治疗 5 天。对照组包括未治疗的动物和多西环素治疗的动物（5 mg/kg/天）。感染后 9 天，所有未治疗的动物均死亡。所有接受治疗的仓鼠均存活至研究结束（第 21 天）。与未治疗组相比，研究组的生存率显著提高（P <.01）。米诺环素和替加环素的生存获益与标准治疗药物多西环素相当。在没有多西环素的情况下，米诺环素可以作为替代药物，而替加环素可能对明确诊断前严重感染的患者的治疗有用。
