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本文引用的文献

1
Antimicrobial therapy of leptospirosis.钩端螺旋体病的抗菌治疗。
Curr Opin Infect Dis. 2006 Dec;19(6):533-7. doi: 10.1097/QCO.0b013e3280106818.
2
Efficacy of macrolides and telithromycin against leptospirosis in a hamster model.大环内酯类药物和泰利霉素在仓鼠模型中抗钩端螺旋体病的疗效。
Antimicrob Agents Chemother. 2006 Jun;50(6):1989-92. doi: 10.1128/AAC.01467-05.
3
Use of ciprofloxacin for treating leptospirosis--need for clinical trials.环丙沙星用于治疗钩端螺旋体病——临床试验的必要性。
J Med Microbiol. 2005 Sep;54(Pt 9):907. doi: 10.1099/jmm.0.45978-0.
4
Determination of susceptibilities of 26 Leptospira sp. serovars to 24 antimicrobial agents by a broth microdilution technique.采用肉汤微量稀释技术测定26种钩端螺旋体血清型对24种抗菌药物的敏感性。
Antimicrob Agents Chemother. 2004 Oct;48(10):4002-5. doi: 10.1128/AAC.48.10.4002-4005.2004.
5
Broth microdilution susceptibility testing for Leptospira spp.钩端螺旋体属肉汤微量稀释药敏试验
Antimicrob Agents Chemother. 2004 May;48(5):1548-52. doi: 10.1128/AAC.48.5.1548-1552.2004.
6
Pharmacodynamics of levofloxacin and ciprofloxacin in a murine pneumonia model: peak concentration/MIC versus area under the curve/MIC ratios.左氧氟沙星和环丙沙星在小鼠肺炎模型中的药效学：峰浓度/最低抑菌浓度与曲线下面积/最低抑菌浓度比值
Antimicrob Agents Chemother. 2003 Sep;47(9):2749-55. doi: 10.1128/AAC.47.9.2749-2755.2003.
7
Pharmacodynamics of the new fluoroquinolone gatifloxacin in murine thigh and lung infection models.新型氟喹诺酮类药物加替沙星在小鼠大腿和肺部感染模型中的药效学
Antimicrob Agents Chemother. 2002 Jun;46(6):1665-70. doi: 10.1128/AAC.46.6.1665-1670.2002.
8
Quantitative PCR assay to evaluate ampicillin, ofloxacin, and doxycycline for treatment of experimental leptospirosis.用于评估氨苄西林、氧氟沙星和强力霉素治疗实验性钩端螺旋体病效果的定量聚合酶链反应检测法。
Antimicrob Agents Chemother. 2002 Mar;46(3):848-53. doi: 10.1128/AAC.46.3.848-853.2002.
9
In vitro and in vivo efficacies of T-3811ME (BMS-284756) against Mycoplasma pneumoniae.T-3811ME（BMS-284756）对肺炎支原体的体外和体内疗效
Antimicrob Agents Chemother. 2001 Jan;45(1):312-5. doi: 10.1128/AAC.45.1.312-315.2001.
10
Pharmacodynamic activities of ciprofloxacin and sparfloxacin in a murine pneumococcal pneumonia model: relevance for drug efficacy.环丙沙星和司帕沙星在小鼠肺炎球菌肺炎模型中的药效学活性：与药物疗效的相关性
J Pharmacol Exp Ther. 1998 Jul;286(1):29-35.

氟喹诺酮类药物在仓鼠模型中对问号钩端螺旋体的疗效。

Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model.

作者信息

Griffith Matthew E, Moon James E, Johnson Erica N, Clark Kyra P, Hawley Joshua S, Hospenthal Duane R, Murray Clinton K

机构信息

Infectious Disease Service, MCHE-MDI, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA.

出版信息

Antimicrob Agents Chemother. 2007 Jul;51(7):2615-7. doi: 10.1128/AAC.00240-07. Epub 2007 Apr 30.

DOI:10.1128/AAC.00240-07
PMID:17470646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1913230/
Abstract

Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

摘要

对环丙沙星、加替沙星和左氧氟沙星预防感染问号钩端螺旋体波特兰变种致死接种量的仓鼠死亡的能力进行了评估。与未治疗相比，每种药物都产生了具有统计学意义的生存优势，并且显示出与强力霉素治疗相似的生存率。