氟喹诺酮类药物在仓鼠模型中对问号钩端螺旋体的疗效。
Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model.
作者信息
Griffith Matthew E, Moon James E, Johnson Erica N, Clark Kyra P, Hawley Joshua S, Hospenthal Duane R, Murray Clinton K
机构信息
Infectious Disease Service, MCHE-MDI, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA.
出版信息
Antimicrob Agents Chemother. 2007 Jul;51(7):2615-7. doi: 10.1128/AAC.00240-07. Epub 2007 Apr 30.
Abstract
Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.
摘要
对环丙沙星、加替沙星和左氧氟沙星预防感染问号钩端螺旋体波特兰变种致死接种量的仓鼠死亡的能力进行了评估。与未治疗相比，每种药物都产生了具有统计学意义的生存优势，并且显示出与强力霉素治疗相似的生存率。
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