School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining 272013, Shandong Province, PR China.
Schizophr Res. 2012 Jan;134(1):89-94. doi: 10.1016/j.schres.2011.09.029. Epub 2011 Oct 21.
Animal studies have strongly implicated a role of S100B in spatial ability and our recent study of humans found that S100B gene polymorphisms (rs9722, rs1051169, and rs2839357) were associated with schizophrenia patients' spatial ability (as assessed by a block design task and a mental rotation task). In this study, we explored the associations between these and three additional SNPs in S100B and prefrontal functions (working memory and executive control) among 434 schizophrenia patients and 412 healthy controls. Results showed that, for both schizophrenia patients and healthy controls, two SNPs were significantly associated with prefrontal functions in the spatial domain (P value threshold was set at 0.014 after correcting for multiple comparisons), with the AA genotype of rs9722 and the GG genotype of rs2839357 linked to poorer performance. No SNP was associated with prefontal functions in the verbal domain (all Ps >0.05). These results extend our previous study and further confirm the important roles of the S100B gene in spatial abilities.
动物研究强烈表明 S100B 在空间能力中起作用，我们最近对人类的研究发现，S100B 基因多态性（rs9722、rs1051169 和 rs2839357）与精神分裂症患者的空间能力相关（通过一项积木设计任务和一项心理旋转任务评估）。在这项研究中，我们探索了这三个额外的 S100B 中的 SNP 与 434 名精神分裂症患者和 412 名健康对照者的前额叶功能（工作记忆和执行控制）之间的关联。结果表明，对于精神分裂症患者和健康对照组，两个 SNP 与空间域的前额叶功能显著相关（在进行多次比较校正后，P 值阈值设定为 0.014），rs9722 的 AA 基因型和 rs2839357 的 GG 基因型与较差的表现相关。没有 SNP 与言语域的前额叶功能相关（所有 P 值均大于 0.05）。这些结果扩展了我们之前的研究，并进一步证实了 S100B 基因在空间能力中的重要作用。
