Li Jing, Shan Ruo-Bing, Liu Rui-Hai, Xu Ying-Jun, Qu Ni-Yan, Pan Gui-Mei, Zhang Na, Yang Na, Chen Zhen-Zhen, Zhang Wen-Xiang, Li Zi-Pu
Department of Pediatric Intensive Care Unit, Critical Care Medicine Center, Women and Children's Hospital, Qingdao University, Qingdao, Shandong 266000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Aug;19(8):904-907. doi: 10.7499/j.issn.1008-8830.2017.08.011.
To investigate the association between rs9722 polymorphisms in the S100B gene and hand, foot and mouth disease (HFMD) caused by enterovirus 71.
A total of 124 HFMD children with enterovirus 71 infection were enrolled as subjects, and 56 healthy children were enrolled as control group. The rs9722 polymorphisms in the S100B gene were detected for both groups, and the serum level of S100B protein was measured for 74 HFMD children.
The rs9722 locus of the S100B gene had three genotypes, CC, CT, and TT, and the genotype frequencies were in accordance with Hardy-Weinberg equilibrium. Compared with the control group, the HFMD group had significant increases in the frequencies of TT genotype and T allele (P<0.01). Children with severe HFMD caused by enterovirus 71 infection had significantly higher frequencies of TT genotype and T allele than those with moderate or mild HFMD (P<0.05). Compared with the cured patients, the patients with poor prognosis had significant increases in the frequencies of TT genotype and T allele in the rs9722 locus of the S100B gene (P<0.05). Among the 74 children with HFMD, the children with TT genotype had the highest serum level of S100B protein, and those with CC genotype had the lowest level (P<0.01).
T allele in the rs9722 locus of the S100B gene might be a risk factor for severe HFMD caused by enterovirus 71 infection.
探讨S100B基因rs9722多态性与肠道病毒71型所致手足口病（HFMD）之间的关联。
共纳入124例肠道病毒71型感染的手足口病患儿作为研究对象，另纳入56例健康儿童作为对照组。检测两组S100B基因rs9722多态性，并对74例手足口病患儿测定血清S100B蛋白水平。
S100B基因rs9722位点有CC、CT和TT三种基因型，其基因型频率符合Hardy-Weinberg平衡。与对照组相比，手足口病组TT基因型和T等位基因频率显著升高（P<0.01）。肠道病毒71型感染所致重症手足口病患儿的TT基因型和T等位基因频率显著高于轻症或中症患儿（P<0.05）。与治愈患者相比，预后不良患者S100B基因rs9722位点的TT基因型和T等位基因频率显著升高（P<0.05）。在74例手足口病患儿中，TT基因型患儿血清S100B蛋白水平最高，CC基因型患儿最低（P<0.01）。
S100B基因rs9722位点的T等位基因可能是肠道病毒71型感染所致重症手足口病的危险因素。
