更多内容即将呈现：多发性硬化症中的体液免疫反应。

More to come: humoral immune responses in MS.

机构信息

Centre for Neuroscience and Trauma, Blizard Institute of Cell and Molecular Science, London E1 2AT, UK.

出版信息

J Neuroimmunol. 2011 Dec 15;240-241:13-21. doi: 10.1016/j.jneuroim.2011.09.009. Epub 2011 Oct 21.

DOI:10.1016/j.jneuroim.2011.09.009

PMID:22019113

Abstract

Interest in the role of B-cells in multiple sclerosis (MS) pathogenesis has increased, and a number of B-cell targeted therapies are currently in clinical trials. B-cells are key mediators of the humoral immune response, with roles including antibody production and acting as antigen presenting cells. Whilst previously, the presence of B-cells within MS plaques has been thought to be secondary to T-cell dysregulation, it is now becoming clear that B-cells play an independent role in disease. In this review we will discuss the potential role of B-cells in MS, how this influences our understanding of the disease, and potential therapeutic implications.

摘要

人们对 B 细胞在多发性硬化症 (MS) 发病机制中的作用越来越感兴趣，目前有许多针对 B 细胞的靶向治疗正在临床试验中。B 细胞是体液免疫反应的关键介质，其作用包括产生抗体和充当抗原呈递细胞。虽然以前认为 MS 斑块内 B 细胞的存在是 T 细胞失调的继发结果，但现在越来越清楚的是，B 细胞在疾病中发挥独立作用。在这篇综述中，我们将讨论 B 细胞在 MS 中的潜在作用，以及这如何影响我们对该疾病的理解，以及潜在的治疗意义。