Department of Human Physiology, Flinders University, South Australia, Australia.
Curr Opin Pharmacol. 2011 Dec;11(6):624-9. doi: 10.1016/j.coph.2011.10.002. Epub 2011 Oct 21.
Colonic motor abnormalities are implicated in several gastrointestinal disorders including constipation, irritable bowel syndrome and functional diarrhoea. Defining the colonic abnormalities is difficult and several novel techniques including, high-resolution fibre optic manometry, wireless motility capsules, ultrasound and magnetic resonance imaging have emerged to help in the diagnosis of these conditions. Coupled with the developing techniques are the novel treatments that look to restore normal colonic motility. These treatments include pharmacological agents (pharmabiotics, serotonin agonist, secretagogues) and medical devices (sacral nerve stimulation, transcutaneous electrical stimulation and biofeedback). This review summarizes the novel techniques used to record and define colonic motor abnormalities and the current status of the emerging treatments used to treat them.
结肠运动异常与包括便秘、肠易激综合征和功能性腹泻在内的几种胃肠道疾病有关。定义结肠异常具有一定难度，几种新的技术，包括高分辨率光纤测压法、无线动力胶囊、超声和磁共振成像，已经出现来帮助诊断这些疾病。与新技术相结合的是旨在恢复正常结肠动力的新疗法。这些治疗方法包括药物（益生菌、血清素激动剂、分泌剂）和医疗设备（骶神经刺激、经皮电刺激和生物反馈）。这篇综述总结了用于记录和定义结肠运动异常的新技术，以及用于治疗这些疾病的新兴疗法的现状。
