维生素D缺乏与美国原住民儿童患糖尿病的风险相关。
Vitamin D insufficiency is associated with diabetes risk in Native American children.
作者信息
Nsiah-Kumi Phyllis A, Erickson Judi M, Beals Jennifer L, Ogle Eric A, Whiting Mary, Brushbreaker Connie, Borgeson Claudia D, Qiu Fang, Yu Fang, Larsen Jennifer L
机构信息
Internal Medicine-Pediatrics,, University of Nebraska Medical Center, Omaha, NE 68198-4085, USA.
出版信息
Clin Pediatr (Phila). 2012 Feb;51(2):146-53. doi: 10.1177/0009922811417290. Epub 2011 Oct 20.
AIMS/HYPOTHESIS: Vitamin D insufficiency has not been well studied in Native American (NA) children, who are at risk for obesity and diabetes. The authors examined vitamin D insufficiency and its association with body mass index (BMI) and insulin resistance.
METHODS
In a cross-section of NA children 5 to 18 years old (N = 198), anthropometrics, biomarkers of insulin resistance, and 25-hydroxy-vitamin D concentration [25(OH) vitamin D] were measured. BMI% and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated.
RESULTS
Mean age was 10.8 ± 0.3 years (mean ± SEM). Mean serum 25(OH) vitamin D was 17.8 ± 0.4 ng/mL and 97% had vitamin D insufficiency [25(OH) vitamin D <30 ng/mL]. After adjusting for BMI, 25(OH) vitamin D was inversely associated with HOMA-IR (P < .0001) and several other markers of insulin resistance.
CONCLUSIONS/INTERPRETATION: Vitamin D insufficiency was nearly universal in this cohort of NA children and was associated with diabetes and vascular risk markers. Whether vitamin D supplementation can improve insulin resistance must be studied further.
目的/假设：维生素D缺乏症在有肥胖和糖尿病风险的美国原住民（NA）儿童中尚未得到充分研究。作者研究了维生素D缺乏症及其与体重指数（BMI）和胰岛素抵抗的关系。
方法
对198名5至18岁的NA儿童进行横断面研究，测量人体测量学指标、胰岛素抵抗生物标志物和25-羟基维生素D浓度[25(OH)维生素D]。计算BMI百分比和胰岛素抵抗稳态模型评估（HOMA-IR）。
结果
平均年龄为10.8±0.3岁（平均值±标准误）。血清25(OH)维生素D平均水平为17.8±0.4 ng/mL，97%的儿童存在维生素D缺乏症[25(OH)维生素D<30 ng/mL]。在调整BMI后，25(OH)维生素D与HOMA-IR呈负相关（P<.0001）以及与其他几种胰岛素抵抗标志物呈负相关。
结论/解读：在这个NA儿童队列中，维生素D缺乏症几乎普遍存在，并且与糖尿病和血管风险标志物相关。维生素D补充剂是否能改善胰岛素抵抗必须进一步研究。
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