Neurorehabilitation Ward, III General Hospital in Lodz, Lodz, Milionowa 14, Poland.
Clin Biochem. 2012 Jan;45(1-2):26-30. doi: 10.1016/j.clinbiochem.2011.09.021. Epub 2011 Oct 14.
Oxidative stress plays an important role in multiple sclerosis (MS).
The present study was designed to evaluate the modifications of plasma proteins by estimation markers of oxidative/nitrosative stress: carbonyl groups and 3-nitrotyrosines (3-NT) levels in relapsing-remitting (RR) (n=10) and secondary progressive (SP) (n=10) clinical course of multiple sclerosis. Moreover, we estimated the level of uric acid (UA) in plasma of MS patients.
Compared to controls (n=10), the levels of carbonyl groups in plasma proteins were elevated (P<0.0001) as well in RRMS as in SPMS. The highest concentration of 3-NT was observed in plasma proteins obtained from SPMS patients (P<0.0005). The level of uric acid in plasma was significantly lower in RRMS (P<0.0001) than SPMS.
This is the first report which presented differences between SPMS and RRMS patients in 3-NT and protein carbonyl groups in plasma proteins.
氧化应激在多发性硬化症（MS）中起着重要作用。
本研究旨在通过评估氧化/硝化应激的标志物：羰基和 3-硝基酪氨酸（3-NT）水平，来评估复发缓解型（RR）（n=10）和继发进展型（SP）（n=10）多发性硬化症的临床病程中血浆蛋白的变化。此外，我们还估计了多发性硬化症患者血浆中尿酸（UA）的水平。
与对照组（n=10）相比，RRMS 和 SPMS 患者血浆蛋白中的羰基水平均升高（P<0.0001）。从 SPMS 患者获得的血浆蛋白中观察到 3-NT 的浓度最高（P<0.0005）。RRMS 患者血浆中的尿酸水平明显低于 SPMS（P<0.0001）。
这是第一个报告，提出了 SPMS 和 RRMS 患者之间在血浆蛋白中的 3-NT 和蛋白羰基水平的差异。
