Ophthalmology Department, Hospital Clinico Universitario, Valladolid, Spain.
Eye (Lond). 2012 Jan;26(1):159-62. doi: 10.1038/eye.2011.257. Epub 2011 Oct 21.
The aim of this study was to determine the prevalence of ocular and oculodermal melanocytosis (ODM) among patients with uveal melanoma (UM) in a Spanish population.
Retrospective review of the medical records of patients with ODM among patients with UM.
Ten (11 eyes) of 400 patients (2.7%) with UM associated had ODM. The mean age at diagnosis of UM among patients with ODM was 62 years. One patient had bilateral tumours. UM was diagnosed during a routine-examination in two cases. All tumours were medium (7/11) or large (4/11) in size, with a mean maximum base of 13 mm and height of 7 mm. No patient had extraocular extension or metastatic disease at diagnosis. Enucleation was done in five cases and I-125-brachytherapy in six. The mean follow-up was 43 months. One patient died because of metastasis 2 years after enucleation; one patient is currently on treatment of systemic metastasis 11 years after.
ODM is more frequent in spanish population with UM than in American population. Despite the risk of UM in ODM, it is often diagnosed late when a conservative treatment is not indicated.
本研究旨在确定西班牙人群中葡萄膜黑色素瘤（UM）患者眼皮肤黑素细胞增多症（ODM）的患病率。
回顾性分析 UM 患者中存在 ODM 的患者的病历。
在 400 例 UM 患者中（11 只眼），有 10 例（11 只眼）存在 ODM。ODM 患者的 UM 诊断平均年龄为 62 岁。1 例患者为双侧肿瘤。2 例病例是在常规检查中诊断出 UM 的。所有肿瘤均为中等（7/11）或大型（4/11），平均最大基底为 13mm，高度为 7mm。诊断时无患者有眼外扩展或转移疾病。5 例患者行眼球摘除术，6 例患者行 I-125 近距离放射治疗。平均随访时间为 43 个月。1 例患者在眼球摘除术后 2 年因转移而死亡；1 例患者在 11 年后因全身转移而正在接受治疗。
ODM 在西班牙 UM 人群中的发病率高于美国人群。尽管 ODM 存在 UM 的风险，但往往在不适合保守治疗时被诊断为晚期。
