MedImmune LLC, Granta Park, Cambridge, UK.
Drug Discov Today. 2011 Dec;16(23-24):1031-6. doi: 10.1016/j.drudis.2011.10.001. Epub 2011 Oct 13.
Quantitative and systems pharmacology (QSP) is an emerging modelling technique that combines the flexibility of systems biology and tractability of compartmental pharmacokinetic-pharmacodynamic modelling techniques. Historically, there has been extensive use of QSP within the field of pharmacokinetics to optimise drug biopharmaceutical properties. However, application to target and biomarker selection, and design of preclinical and clinical studies is limited, but growing rapidly. In this article we highlight the impact of QSP within drug discovery and development by citing examples from within the field of pharmacology and we argue for a more systematic integration of QSP within the drug discovery and development paradigm.
定量系统药理学（QSP）是一种新兴的建模技术，它结合了系统生物学的灵活性和房室药代动力学-药效动力学建模技术的可处理性。从历史上看，在药代动力学领域广泛使用 QSP 来优化药物的生物制药特性。然而，它在靶标和生物标志物选择以及临床前和临床研究设计中的应用有限，但正在迅速增长。在本文中，我们通过引用药理学领域的例子来强调 QSP 在药物发现和开发中的影响，并主张在药物发现和开发范式中更系统地整合 QSP。
