Faculty of Medicine at King's College, University of London, UK.
J Clin Psychopharmacol. 2011 Dec;31(6):740-4. doi: 10.1097/JCP.0b013e318234ee3b.
Stuttering affects approximately 5% of children up to the teenage years. There are many possible forms of intervention, one of which is pharmacotherapy. No review about the treatment of stuttering with pharmacological agents in children and adolescents has been undertaken. The objectives of this review were to determine the extent of previous research in this area and to assess the success of pharmacological agents in reducing the frequency of disfluency in child and adolescent stutterers (<18 years). A systematic search of MEDLINE, PsychInfo, Embase, and Cochrane Systematic Review databases was carried out to identify potential studies for the review. Studies that met specified criteria were selected for detailed examination, and the quality of evidence they provided was assessed according to 7 criteria that pertained to study design and data provision. Seven publications met the inclusion criteria for the review. Only 1 publication was classified as strong evidence quality, and this reported that clonidine did not reduce the frequency of disfluency in a group of 25 individuals who stuttered. All further publications were classified as either very low or low evidence quality. The agents examined were risperidone, olanzapine, clonidine, tiapride, haloperidol, and chlorpromazine.
口吃影响大约 5%的儿童到青少年时期。有许多可能的干预形式，其中之一是药物治疗。目前还没有关于药物治疗儿童和青少年口吃的综述。本综述的目的是确定该领域以前研究的程度，并评估药物在减少儿童和青少年口吃者（<18 岁）言语不流畅频率方面的效果。系统地检索了 MEDLINE、PsychInfo、Embase 和 Cochrane 系统评价数据库，以确定综述的潜在研究。符合特定标准的研究被选择进行详细检查，并根据与研究设计和数据提供相关的 7 条标准评估它们提供的证据质量。有 7 篇出版物符合综述的纳入标准。只有 1 篇出版物被归类为高质量证据，该研究报告氯苯甲嗪并不能减少 25 名口吃者的言语不流畅频率。所有进一步的出版物都被归类为低或极低质量证据。检查的药物有利培酮、奥氮平、氯苯甲嗪、硫必利、氟哌啶醇和氯丙嗪。
