Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Int J Hematol. 2011 Nov;94(5):491-4. doi: 10.1007/s12185-011-0952-2. Epub 2011 Oct 22.
Mast cell sarcoma is a rare disease characterized by localized, but destructive and rapid, growth of the tumor, high risk of distant metastasis, possibility of a leukemic phase, and poor prognosis. We report successful treatment of uterine mast cell sarcoma with imatinib in a 39-year-old woman who presented with abdominal distention and massive ascites. Routine treatment, such as combined chemotherapy, had little effect. We administered imatinib to the patient and achieved a good response in the absence of c-kit mutation, BCR/ABL, and FIP1L1-PDGFRα. Our results indicate that imatinib is of potential use in the treatment of mast cell sarcoma.
肥大细胞瘤肉瘤是一种罕见的疾病，其特征为肿瘤局部但具有破坏性且快速生长、远处转移风险高、可能出现白血病期和预后不良。我们报告了一例 39 岁女性因腹胀和大量腹水就诊，经伊马替尼治疗成功的子宫肥大细胞瘤肉瘤病例。常规治疗，如联合化疗，效果甚微。我们给患者使用伊马替尼，在没有 c-kit 突变、BCR/ABL 和 FIP1L1-PDGFRα 的情况下取得了良好的反应。我们的结果表明，伊马替尼可能对肥大细胞瘤肉瘤的治疗有用。
