异基因造血干细胞移植治疗罕见的扁桃体肥大细胞肉瘤病例
Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma.
作者信息
Kubasch Anne Sophie, Franke Georg-Nikolaus, Aldaoud Ali, Weibl Konstantin, Jentzsch Madlen, Sabri Osama, Horny Hans-Peter, Fend Falko, Behre Gerhard, Platzbecker Uwe, Vucinic Vladan
机构信息
Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany.
Outpatient-Centre for Hematology and Oncology, Leipzig, Germany.
出版信息
Front Oncol. 2020 Feb 28;10:219. doi: 10.3389/fonc.2020.00219. eCollection 2020.
Mast cell sarcoma comprises a rare aggressive mast cell neoplasia with histological, clinical, and genetic features distinct from other mast cell neoplasm. Until now, prognosis is still poor due to high rates of progression to mast cell leukemia and failure of conventional chemotherapies. Our here presented first report about successful allogeneic hematopoietic stem cell transplantation leading to remission in a case of tonsillar MCS represents a promising potential curative treatment option for this rare and often fatal disease.
肥大细胞肉瘤是一种罕见的侵袭性肥大细胞肿瘤，具有与其他肥大细胞肿瘤不同的组织学、临床和遗传学特征。到目前为止，由于进展为肥大细胞白血病的发生率高以及传统化疗失败，预后仍然很差。我们在此首次报告了一例扁桃体肥大细胞肉瘤患者通过异基因造血干细胞移植成功缓解的病例，这为这种罕见且往往致命的疾病提供了一种有前景的潜在治愈性治疗选择。
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