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Epilepsy in a dish: an in vitro model of epileptogenesis.培养皿中的癫痫：癫痫发生的体外模型
Epilepsy Curr. 2011 Sep;11(5):153-4. doi: 10.5698/1535-7511-11.5.153.
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Calcium-dependent epileptogenesis in an in vitro model of stroke-induced "epilepsy".在中风诱导的“癫痫”体外模型中的钙依赖性癫痫发生
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3
Neural stem cells and epilepsy: functional roles and disease-in-a-dish models.神经干细胞与癫痫：功能作用和疾病在玻璃器皿中的模型。
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An in vitro model of stroke-induced epilepsy: elucidation of the roles of glutamate and calcium in the induction and maintenance of stroke-induced epileptogenesis.中风诱导癫痫的体外模型：阐明谷氨酸和钙在中风诱导癫痫发生的起始和维持中的作用。
Int Rev Neurobiol. 2007;81:59-84. doi: 10.1016/S0074-7742(06)81005-6.
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A Brain-Heart Biomarker for Epileptogenesis.脑-心生物标志物与癫痫发生。
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Epigenetics of Epileptogenesis-Evoked Upregulation of Matrix Metalloproteinase-9 in Hippocampus.癫痫发生引起的海马区基质金属蛋白酶-9上调的表观遗传学
PLoS One. 2016 Aug 9;11(8):e0159745. doi: 10.1371/journal.pone.0159745. eCollection 2016.
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Glial source of nitric oxide in epileptogenesis: A target for disease modification in epilepsy.癫痫发生中的一氧化氮的神经胶质来源：癫痫疾病修饰的靶点。
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Epileptogenesis induces long-term alterations in intracellular calcium release and sequestration mechanisms in the hippocampal neuronal culture model of epilepsy.在癫痫的海马神经元培养模型中，癫痫发生会诱导细胞内钙释放和隔离机制的长期改变。
Cell Calcium. 2001 Oct;30(4):285-96. doi: 10.1054/ceca.2001.0236.
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MicroRNAs and target genes in epileptogenesis.微小 RNA 与癫痫发生中的靶基因。
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Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.在两种颞叶癫痫大鼠模型中，癫痫持续状态和随后的癫痫发生期间海马乙酰胆碱和氨基酸神经递质细胞外水平的共同性和差异性。
Brain Res. 2019 Jun 1;1712:109-123. doi: 10.1016/j.brainres.2019.01.034. Epub 2019 Jan 28.

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Modeling seizure networks in neuron-glia cultures using microelectrode arrays.使用微电极阵列对神经胶质细胞培养物中的癫痫发作网络进行建模。
Front Netw Physiol. 2024 Sep 3;4:1441345. doi: 10.3389/fnetp.2024.1441345. eCollection 2024.
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NORSE/FIRES: how can we advance our understanding of this devastating condition?北欧卒中/发热性疾病相关性癫痫综合征：我们如何增进对这种毁灭性病症的理解？
Front Neurol. 2024 Aug 8;15:1426051. doi: 10.3389/fneur.2024.1426051. eCollection 2024.
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High and Low-Frequency Stimulation Effect on Epileptiform Activity in Brain Slices.高低频刺激对脑片癫痫样活动的影响
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Lab-on-Chip Microsystems for Network of Neurons Studies: A Review.用于神经元网络研究的片上实验室微系统：综述
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New Insights Into the Role of Aberrant Hippocampal Neurogenesis in Epilepsy.海马体异常神经发生在癫痫中作用的新见解
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Extract Depresses Excitatory Synaptic Transmission and Chemically-Induced Seizures in the Rat Hippocampus.提取物抑制大鼠海马体中的兴奋性突触传递和化学诱导的癫痫发作。
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A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.系统级药物发现框架将 CSF1R 鉴定为一种抗癫痫药物靶点。
Nat Commun. 2018 Sep 3;9(1):3561. doi: 10.1038/s41467-018-06008-4.
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The class 4 semaphorin Sema4D promotes the rapid assembly of GABAergic synapses in rodent hippocampus.第四类信号蛋白 Sema4D 促进了啮齿动物海马体内 GABA 能突触的快速形成。
J Neurosci. 2013 May 22;33(21):8961-73. doi: 10.1523/JNEUROSCI.0989-13.2013.

本文引用的文献

1
Interictal spikes: harbingers or causes of epilepsy?发作间期棘波：癫痫的先兆还是病因？
Neurosci Lett. 2011 Jun 27;497(3):247-50. doi: 10.1016/j.neulet.2011.03.070. Epub 2011 Mar 31.
2
An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.一种兴奋性损伤诱导自发重复癫痫样放电的器官型海马脑片培养模型。
Brain Res. 2011 Jan 31;1371:110-20. doi: 10.1016/j.brainres.2010.11.065. Epub 2010 Nov 25.
3
Interictal spikes precede ictal discharges in an organotypic hippocampal slice culture model of epileptogenesis.在癫痫发生的器官型海马切片培养模型中，发作间期棘波先于发作放电。
J Clin Neurophysiol. 2010 Dec;27(6):418-24. doi: 10.1097/WNP.0b013e3181fe0709.
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EEG spike activity precedes epilepsy after kainate-induced status epilepticus.红藻氨酸诱导癫痫持续状态后，脑电图尖峰活动先于癫痫发作。
Epilepsia. 2010 Mar;51(3):371-83. doi: 10.1111/j.1528-1167.2009.02339.x. Epub 2009 Oct 20.
5
Epileptiform activity in rat hippocampus strengthens excitatory synapses.大鼠海马体中的癫痫样活动增强兴奋性突触。
J Physiol. 2004 Jan 15;554(Pt 2):439-48. doi: 10.1113/jphysiol.2003.052662. Epub 2003 Oct 31.
6
Seizures, cell death, and mossy fiber sprouting in kainic acid-treated organotypic hippocampal cultures.在经海藻酸处理的海马脑片培养物中出现的癫痫发作、细胞死亡和苔藓纤维发芽。
Neuroscience. 1999;94(3):755-65. doi: 10.1016/s0306-4522(99)00358-9.
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Epileptiform activity induced by low Mg2+ in cultured rat hippocampal slices.
Brain Res. 1999 Jan 9;815(2):294-303. doi: 10.1016/s0006-8993(98)01102-0.
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A novel in vitro preparation: the intact hippocampal formation.
Neuron. 1997 Oct;19(4):743-9. doi: 10.1016/s0896-6273(00)80956-3.
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Organotypic slice cultures: a technique has come of age.器官型切片培养：一项技术已走向成熟。
Trends Neurosci. 1997 Oct;20(10):471-7. doi: 10.1016/s0166-2236(97)01122-3.
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Hippocampal slices in experimental and human epilepsy.实验性癫痫和人类癫痫中的海马切片
Adv Neurol. 1986;44:991-1010.

Epilepsy in a dish: an in vitro model of epileptogenesis.

作者信息

Wong Michael

出版信息

Epilepsy Curr. 2011 Sep;11(5):153-4. doi: 10.5698/1535-7511-11.5.153.

DOI:10.5698/1535-7511-11.5.153
PMID:22020786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3193099/
Abstract
摘要