Chen Peng, Chen Fuchao, Wu Yue, Zhou Benhong
Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, China.
Front Neurol. 2021 Dec 15;12:727065. doi: 10.3389/fneur.2021.727065. eCollection 2021.
Data accumulated over the past four decades have confirmed that adult hippocampal neurogenesis (HN) plays a key role in the wide spectrum of hippocampal pathology. Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although neurogenesis in persistent germinative zones is altered in the adult rodent models of epilepsy, the effects of seizure-induced neurogenesis in the epileptic brain, in terms of either a pathological or reparative role, are only beginning to be explored. In this review, we described the most recent advances in neurogenesis in epilepsy and outlooked future directions for neural stem cells (NSCs) and epilepsy-in-a-dish models. We proposed that it may help in refining the underlying molecular mechanisms of epilepsy and improving the therapies and precision medicine for patients with epilepsy.
过去四十年来积累的数据证实，成体海马神经发生（HN）在广泛的海马病理学中起关键作用。癫痫是一种中枢神经系统疾病，其特征为自发性反复癫痫发作。尽管在成年啮齿动物癫痫模型中，持续生发区的神经发生会发生改变，但癫痫发作诱导的神经发生在癫痫脑内的病理或修复作用，才刚刚开始被探索。在这篇综述中，我们描述了癫痫神经发生的最新进展，并展望了神经干细胞（NSCs）和癫痫体外模型的未来方向。我们提出，这可能有助于完善癫痫的潜在分子机制，并改善癫痫患者的治疗和精准医学。
