Na Youn Ju, Kim Eun Ran, Kim Seok Jin, Kim Won Seog, Ko Young-Hyeh, Son Hee Jung
Samsung Medical Center, Seoul, Korea.
Hepatogastroenterology. 2012 May;59(115):751-3. doi: 10.5754/hge11569.
BACKGROUND/AIMS: Primary gastrointestinal follicular lymphoma (GI-FL) is very rare and its natural course is barley known. This study aimed to evaluate the clinical characteristics of primary gastrointestinal follicular lymphoma (GI-FL).
From May 1996 to October 2008, the records of five patients diagnosed with primary GI-FL were retrieved from pathological files and retrospectively analyzed in terms of characteristics of endoscopic and clinical findings.
The five patients consisted of 3 males and 2 females with a median age of 52 years. Abdominal pain was the most common (n=4, 80%) symptom. The most frequent site was the terminal ileum in the small bowel (n=3, 60%). Endoscopic findings were 3 of mass forming type, 1 of irregular ulcer type and 1 of whitish granular type. Three cases (60%) had a component of diffuse large B cell lymphoma. All cases received chemotherapy. While complete remission occurred in every patient, relapse occurred in the two patients with a higher grade and more advanced stage than the other cases. At a median follow-up time of 37 months (range, 27-58 months; mean, 38.8 months), four patients (80%) were disease free and one patient had died of cardiovascular disease.
In South Korea, primary gastrointestinal follicular lymphoma is very rare and symptomatic. Endoscopic findings were variable from early whitish granular lesions to advanced mass forming lesions.
背景/目的：原发性胃肠道滤泡性淋巴瘤（GI-FL）非常罕见，其自然病程鲜为人知。本研究旨在评估原发性胃肠道滤泡性淋巴瘤（GI-FL）的临床特征。
从1996年5月至2008年10月，从病理档案中检索出5例诊断为原发性GI-FL的患者记录，并对其内镜和临床特征进行回顾性分析。
5例患者中男性3例，女性2例，中位年龄52岁。腹痛是最常见的症状（n = 4，80%）。最常见的部位是小肠末端回肠（n = 3，60%）。内镜检查结果为肿块形成型3例，不规则溃疡型1例，白色颗粒型1例。3例（60%）有弥漫性大B细胞淋巴瘤成分。所有病例均接受化疗。虽然每位患者均达到完全缓解，但2例分级较高、分期较晚的患者出现复发。中位随访时间为37个月（范围27 - 58个月；平均38.8个月），4例（80%）患者无病生存，1例患者死于心血管疾病。
在韩国，原发性胃肠道滤泡性淋巴瘤非常罕见且有症状。内镜检查结果从早期的白色颗粒状病变到晚期的肿块形成病变各不相同。
