Vakulenko V I, Sapargel'dyev N B, Golub G B
Stomatologiia (Mosk). 1990 May-Jun;69(3):9-11.
Soluble and total protein content and cathepsin D activity were measured in rat mandibular bone tissue during healing of a fracture treated with proteolytic enzymes (andecalin) or protease inhibitors (contrykal) electrophoresis. Contrykal essentially elevated collagen content in mandibular bone tissue and reduced lysosomal enzymes activity. Andecalin had no noticeable effect on the levels of total protein and collagen, but it significantly increased the activity of cathepsin D. The findings evidence that local contrykal electrophoresis in the focus of injury creates an effective concentration of the drug that enhances the fracture healing and prevents the development of pyoinflammatory complications.
在用蛋白水解酶（安代卡林）或蛋白酶抑制剂（抑肽酶）进行电泳治疗骨折愈合过程中，对大鼠下颌骨组织中的可溶性蛋白含量、总蛋白含量和组织蛋白酶D活性进行了测定。抑肽酶基本上提高了下颌骨组织中的胶原蛋白含量，并降低了溶酶体酶的活性。安代卡林对总蛋白和胶原蛋白水平没有明显影响，但它显著增加了组织蛋白酶D的活性。这些发现证明，在损伤部位进行局部抑肽酶电泳可产生有效的药物浓度，从而促进骨折愈合并预防脓性炎症并发症的发生。
