Kozlova M V, Ivanov V N, Pinelis I S, Petrovich Iu A
Patol Fiziol Eksp Ter. 1997 Apr-Jun(2):35-7.
The paper presents the results of examining the central part of the rat mandible for a month after its fracture. The rate of free radical oxidation was estimated by the levels of diene conjugates (DC), malonic dialdehyde (MDA) and by the activity of selenium-containing glutathione peroxidase (GPO). The findings suggest that there are profound injury-induced changes in free radical oxidation and antioxidative defense. The levels of DC and MDA showed the maximum upward change as a double-peaked curve and longer restoration to the level seen in control animals. These rats had the minimum enhanced GPO activity. In the animals receiving intragastric selenium methionine or selenium electrophoresis applied to the site of mandible fracture, alterations in DC and MDA were less pronounced and GPO showed a higher activity.
本文呈现了大鼠下颌骨骨折后一个月对其中心部分进行检查的结果。通过二烯共轭物（DC）、丙二醛（MDA）水平以及含硒谷胱甘肽过氧化物酶（GPO）的活性来评估自由基氧化速率。研究结果表明，损伤引起了自由基氧化和抗氧化防御的深刻变化。DC和MDA水平呈现出双峰曲线的最大上升变化，并且恢复到对照动物水平所需的时间更长。这些大鼠的GPO活性增强最小。在接受胃内注射硒蛋氨酸或在下颌骨骨折部位进行硒电泳的动物中，DC和MDA的变化不太明显，并且GPO表现出更高的活性。
