University of Padua, School of Medicine, Department of Surgical and Gastroenterological Sciences, Via Giustiniani 2, 35128 Padova, Italy.
In Vivo. 2011 Nov-Dec;25(6):1027-9.
Neuroendocrine tumors (NETs) of the gastro-entero-pancreatic (GEP) system are a heterogeneous group of cancers more common in the small intestine. In patients with malignant NETs, especially carcinoids, a number of prognostic parameters have been considered, such as age, clinical symptoms related to the neoplasm, TNM staging and histological grade, as well as urinary 5-hydroxyindolacetic acid (5-HIAA), chromogranin A (CgA) and neuron-specific enolase (NSE) serum levels.
The data from a series of 14 patients (median age 56 years, range 33-72 years) with gastric (N=8), ileal (N=1), colorectal (N=4) or appendiceal (N=1) malignant carcinoids were retrospectively reviewed.
The specificity of CgA, NSE, and 5-HIAA was 86%, 86% and 93%, while the sensitivity was 64%, 36%, and 36%, respectively. There was no relationship between survival and or urinary 5-HIAA (R=0.12, p=0.45), CgA (R=0.22, p=0.21) nor serum NSE (R=0.12, p=0.76) levels.
The sensitivity of tumor markers is generally low in patients with malignant carcinoids, and both 5-HIAA and CgA levels are independent of survival.
胃肠胰神经内分泌肿瘤（NETs）是一组异质性癌症，在小肠中更为常见。在恶性 NETs 患者中，特别是类癌，已经考虑了许多预后参数，例如年龄、与肿瘤相关的临床症状、TNM 分期和组织学分级，以及尿 5-羟吲哚乙酸（5-HIAA）、嗜铬粒蛋白 A（CgA）和神经元特异性烯醇化酶（NSE）血清水平。
回顾性分析了 14 例胃（N=8）、回肠（N=1）、结直肠（N=4）或阑尾（N=1）恶性类癌患者的一系列数据（中位年龄 56 岁，范围 33-72 岁）。
CgA、NSE 和 5-HIAA 的特异性分别为 86%、86%和 93%，而敏感性分别为 64%、36%和 36%。生存与尿 5-HIAA（R=0.12，p=0.45）、CgA（R=0.22，p=0.21）或血清 NSE（R=0.12，p=0.76）水平之间均无关系。
恶性类癌患者的肿瘤标志物敏感性一般较低，5-HIAA 和 CgA 水平均与生存无关。
