Okamoto K, Hirai S, Shoji M, Senoh Y, Yamazaki T
Institute of Neurology and Rehabilitation, Gunma University, Japan.
Acta Neuropathol. 1990;80(2):222-6. doi: 10.1007/BF00308929.
In 2 of 16 cases with sporadic amyotrophic lateral sclerosis (ALS) large numbers of axonal swellings were observed in the corticospinal tracts over a region extending from the posterior limbs of internal capsules to the bulbar pyramids. On electron microscopy, these axonal swellings were seen to consist of accumulations of neurofilaments and altered neuronal organelles (mitochondria and secondary lysosomes). Their morphology differed from the spheroids seen in the anterior horn in ALS.
在16例散发性肌萎缩侧索硬化症（ALS）患者中的2例中，在内囊后肢至延髓锥体的区域内，皮质脊髓束中观察到大量轴突肿胀。在电子显微镜下，这些轴突肿胀由神经丝聚集和改变的神经元细胞器（线粒体和次级溶酶体）组成。它们的形态与ALS患者前角中所见的球体不同。
