Jones H B, Cavanagh J B
Neuropathol Appl Neurobiol. 1982 Jul-Aug;8(4):289-301. doi: 10.1111/j.1365-2990.1982.tb00298.x.
Rats were given 2,5-hexanediol in their water for more than 5 weeks. The changes in the optic pathways were studied both qualitatively and quantitatively. Increase in 10-nm filaments within axons was noticeable from 10 days onwards in the superior colliculus and in the brachium of the superior colliculus. From then onwards there was a steady increase in the number of affected axons, and their gross enlargement occurred. The proportion of affected fibres in the brachia was in fact few, but all fibres were of retinotectal origin. Less than half of those in the superior colliculus that were swollen were of retinal origin. Measurement of axon diameter versus myelin sheath thickness showed gross relative thinning of the latter. Axon degeneration did not occur but there was increasing ultrastructural evidence of impairment of transport of organelles both centrifugally and centripetally as the filamentous masses accumulated.
给大鼠饮用含2,5 -己二醇的水超过5周。对视神经通路的变化进行了定性和定量研究。从第10天起，在上丘和上丘臂的轴突内，10纳米细丝数量增加明显。从那时起，受影响轴突的数量稳步增加，且轴突明显增粗。上丘臂中受影响纤维的比例实际上很少，但所有纤维均来自视网膜 - 顶盖。上丘中肿胀的纤维中，不到一半来自视网膜。轴突直径与髓鞘厚度的测量显示髓鞘明显相对变薄。轴突未发生变性，但随着丝状物质的积累，越来越多的超微结构证据表明细胞器的离心和向心运输受损。
