Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Orissa, India.
Indian J Pharmacol. 2011 Sep;43(5):603-4. doi: 10.4103/0253-7613.84983.
Sepsis is a clinical syndrome related to severe infection and is characterized by systemic inflammation and injury to multiple organs and functional systems. Sepsis is one of the main causes of acute renal failure (ARF). Diuretics are frequently administered during ARF. However, there is scant evidence that diuretics provide any benefit to the patients with ARF. This case report highlights the occurrence of uremia and nonrecovery of renal function after administration of diuretics in a patient with ARF caused by sepsis. It is suggested that physicians should be cautious in prescribing diuretics to patients with ARF due to septicemia. Diuretics cause uremia and may lead to false diagnosis of chronic renal failure and nonrecovery of renal function. The patient may unnecessarily require prolonged dialysis.
脓毒症是一种与严重感染相关的临床综合征，其特征为全身炎症和多个器官及功能系统损伤。脓毒症是急性肾衰竭（ARF）的主要病因之一。在 ARF 期间常给予利尿剂。然而，几乎没有证据表明利尿剂对 ARF 患者有益。本病例报告强调了在由脓毒症引起的 ARF 患者中，利尿剂的使用导致尿毒症和肾功能无法恢复。建议医生在为败血症引起的 ARF 患者开利尿剂时应谨慎。利尿剂可导致尿毒症，并可能导致慢性肾衰竭和肾功能无法恢复的误诊。患者可能需要不必要的长时间透析。
