Roche Diagnostics, 6343 Rotkreuz, Switzerland.
Expert Rev Mol Diagn. 2011 Nov;11(8):793-8. doi: 10.1586/erm.11.66.
In recent years, the real time-based TaqMan(®) technology has allowed the development of highly sensitive hepatitis viral load tests with broad dynamic ranges. The increasing applications of these tests in clinical diagnostics have shown the utility of viral load as a predictive marker of treatment response and proven its key role in invidualized antiviral therapies. Future refinement in viral load assays, including higher sensitivity, genotype inclusivity, standardization and automation, will further foster the concept of personalized healthcare in the clinical management of chronic hepatitis C.
近年来，基于实时的 TaqMan(®)技术使得高灵敏度、宽检测范围的乙型肝炎病毒载量检测方法得以开发。这些检测方法在临床诊断中的广泛应用，显示了病毒载量作为治疗应答预测标志物的实用性，并证明了其在个体化抗病毒治疗中的关键作用。未来病毒载量检测方法的改进，包括更高的灵敏度、基因型包容性、标准化和自动化，将进一步推动慢性丙型肝炎临床管理中个性化医疗的概念。
