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相似水动力直径的氧化铜纳米粒子对分化的人肠道 Caco-2 细胞单层的毒性差异部分与铜释放和形状有关。

Differential toxicity of copper (II) oxide nanoparticles of similar hydrodynamic diameter on human differentiated intestinal Caco-2 cell monolayers is correlated in part to copper release and shape.

机构信息

URBC, Namur Research Institute for Life Sciences (NARILIS), University of Namur (FUNDP), Namur, Belgium.

出版信息

Nanotoxicology. 2012 Nov;6(7):789-803. doi: 10.3109/17435390.2011.625127. Epub 2011 Oct 24.

DOI:10.3109/17435390.2011.625127
PMID:22023055
Abstract

The potential toxic effects of copper oxide (CuO) nanoparticles (NPs) were studied on differentiated Caco-2 cell monolayers, a classical in vitro model of human small intestine epithelium. Two types of CuO NPs, with different specific surface area, different sizes as raw material but the same hydrodynamic diameter in suspension, differentially disturbed the monolayer integrity, were cytotoxic and triggered an increase of the abundance of several transcripts coding for pro-inflammatory cytokines and chemokines. Specific surface area was not a major variable explaining the increased toxicity when intestinal epithelium is exposed to rod-shaped CuO NPs, compared with spherical CuO NPs. The results suggest that release of Cu(II) cations and shape of these CuO NPs are likely to be implicated in the toxicity of these CuO NPs.

摘要

研究了氧化铜 (CuO) 纳米粒子 (NPs) 对分化的 Caco-2 细胞单层的潜在毒性作用，Caco-2 细胞单层是人类小肠上皮的经典体外模型。两种类型的 CuO NPs，具有不同的比表面积、不同的粒径（以原始材料计）但在悬浮液中的水动力直径相同，它们对单层完整性产生不同程度的干扰，具有细胞毒性，并引发编码促炎细胞因子和趋化因子的几种转录本的丰度增加。与球形 CuO NPs 相比，当肠上皮暴露于棒状 CuO NPs 时，比表面积不是解释增加毒性的主要变量。结果表明，Cu(II) 阳离子的释放和这些 CuO NPs 的形状可能与这些 CuO NPs 的毒性有关。

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