Kubota S, el-Farrash M A, Maki M, Harada S, Hatanaka M
Institute for Virus Research, Kyoto University, Japan.
AIDS Res Hum Retroviruses. 1990 Jul;6(7):919-27. doi: 10.1089/aid.1990.6.919.
We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.
我们研究了已知的抗重金属中毒药物2,3-二巯基-1-丙醇（DMP）对1型人类免疫缺陷病毒（HIV-1）的作用。我们证明，DMP抑制了由tat蛋白介导的反式激活，tat蛋白是一种含金属的转录反式激活因子，同时也干扰了病毒的产生。此外，用DMP对细胞进行处理和预处理，通过未知机制强烈降低了它们对HIV-1感染的敏感性。这些结果表明，DMP在体外对HIV-1感染和产生显示出多效性作用，因此可能为设计抗艾滋病新药提供一个可利用的假设。
