Bamba Yoshiko, Itabashi Michio, Kameoka Shingo
Department of Surgery II, Tokyo's Women's Medical Univerity, Tokyo, Japan.
Hepatogastroenterology. 2011 Nov-Dec;58(112):1972-4. doi: 10.5754/hge11256.
BACKGROUND/AIMS: Several types of cancer can be clinically diagnosed by PET/CT, which can also perform whole-body imaging based on 18F-fluorodeoxyglucose (FDG) uptake. The present study assesses the value of PET/CT for diagnosing of pulmonary metastasis of colorectal cancer.
We staged or restaged 256 patients with colorectal cancer by PET/CT. Actual and suspected pulmonary metastases were detected in 37 (male, n=23; female, n=14) patients with primary or recurrent colorectal cancer. Among them, 35 (21 males, 14 females) patients had extant homochronous (n=7) and metachronous (n=28) pulmonary metastasis.
The sensitivity and specificity of FDG-PET/CT for pulmonary metastasis were 57.1% and 99.1%, respectively, and the positive and negative predictive values were 90.1% and 93.6%, respectively. The uptake of FDG was affected by the size of the metastatic nodules; uptake was positive and negative in pulmonary metastases with an average size of 14.9mm and 5.75mm, respectively. The limit of positive FDG uptake was reached in pulmonary metastases of about 9mm.
Pulmonary metastasis of colorectal cancer can be accurately and conveniently diagnosed by PET/CT, especially when nodules are >9mm.
背景/目的：几种癌症可通过PET/CT进行临床诊断，PET/CT还可基于18F-氟脱氧葡萄糖（FDG）摄取进行全身成像。本研究评估PET/CT在诊断结直肠癌肺转移中的价值。
我们通过PET/CT对256例结直肠癌患者进行分期或重新分期。在37例（男性23例，女性14例）原发性或复发性结直肠癌患者中检测到实际和疑似肺转移。其中，35例（男性21例，女性14例）患者存在同时性（n = 7）和异时性（n = 28）肺转移。
FDG-PET/CT对肺转移的敏感性和特异性分别为57.1%和99.1%，阳性和阴性预测值分别为90.1%和93.6%。FDG摄取受转移结节大小影响；平均大小为14.9mm和5.75mm的肺转移灶摄取分别为阳性和阴性。FDG阳性摄取的极限在约9mm的肺转移灶中达到。
PET/CT可准确、方便地诊断结直肠癌肺转移，尤其是当结节>9mm时。
