Department of Neurological Surgery, University of California Los Angeles, 695 Charles E. Young Drive South, Gonda 3357, Los Angeles, CA 90095-1761, USA.
J Clin Neurosci. 2012 Jan;19(1):21-6. doi: 10.1016/j.jocn.2011.06.002. Epub 2011 Oct 22.
Epidermoid tumors are intracranial lesions that may occasionally undergo malignant transformation. Although surgical resection is the first-line treatment for malignant epidermoids, postoperative radiotherapy has been intermittently reported with favorable findings. Our analysis identified all previously reported patients with malignant epidermoids treated with surgical resection alone or surgery plus radiotherapy to examine the potential role for this adjuvant therapy. Whereas patients treated with surgery only had an overall survival of 6.6 months, those treated with postoperative radiotherapy demonstrated a statistically significant increase in survival to 12.7 months (log-rank test, p<0.003). Furthermore, the mean dosage of radiation given to this patient population was 52.2 Gy, with no appreciable survival benefit for the utilization of levels of radiation greater than 50 Gy. When determining the management for malignant transformation of epidermoid tumors, the combination of surgical resection and radiotherapy may be associated with improved short-term survival.
表皮样肿瘤是颅内病变，偶尔可能发生恶性转化。虽然手术切除是恶性表皮样肿瘤的一线治疗方法，但术后放疗也有间歇性报道，疗效良好。我们的分析确定了所有以前报道的单独手术或手术加放疗治疗恶性表皮样肿瘤的患者，以检查这种辅助治疗的潜在作用。仅接受手术治疗的患者的总生存率为 6.6 个月，而接受术后放疗的患者的生存率有统计学意义地提高到 12.7 个月（对数秩检验，p<0.003）。此外，该患者人群接受的平均放射剂量为 52.2 Gy，对于使用大于 50 Gy 的放射剂量没有明显的生存获益。在确定表皮样肿瘤恶性转化的治疗方法时，手术切除和放疗的联合应用可能与短期生存的改善相关。
