Cuoco Joshua A, Rogers Cara M, Busch Christopher M, Apfel Lisa S, Entwistle John J, Marvin Eric A
Section of Neurosurgery, Carilion Clinic, Roanoke, VA, United States.
Virginia Tech Carilion School of Medicine, Roanoke, VA, United States.
Front Oncol. 2019 Jul 30;9:694. doi: 10.3389/fonc.2019.00694. eCollection 2019.
Intracranial epidermoid cysts are benign lesions that typically remain asymptomatic; however, although histopathologically benign, these cysts can rarely undergo malignant transformation into squamous cell carcinoma. Primary intracranial squamous cell carcinoma carries a poor prognosis as optimal treatment modalities remain unclear due to their low incidence. Here, we present a case of a cerebellopontine angle epidermoid cyst remnant that underwent malignant transformation into squamous cell carcinoma 40 years after partial resection. To our knowledge, this case establishes the longest time interval to date for an intracranial epidermoid cyst to undergo malignant transformation. We also review the relevant literature and discuss recent retrospective clinical studies that have analyzed the effect of multimodal treatment approaches on survival outcomes in patients with these lesions.
颅内表皮样囊肿是良性病变，通常无症状；然而，尽管这些囊肿在组织病理学上是良性的，但很少会恶变为鳞状细胞癌。原发性颅内鳞状细胞癌预后较差，由于其发病率低，最佳治疗方式仍不明确。在此，我们报告一例桥小脑角表皮样囊肿残余物在部分切除40年后恶变为鳞状细胞癌的病例。据我们所知，该病例是迄今为止颅内表皮样囊肿发生恶变时间间隔最长的。我们还回顾了相关文献，并讨论了最近的回顾性临床研究，这些研究分析了多模式治疗方法对这些病变患者生存结果的影响。
