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1
Pretreatment with rh-GMCSF, but not rh-IL3, enhances PAF-induced eosinophil accumulation in guinea-pig airways.用重组人粒细胞巨噬细胞集落刺激因子（rh-GMCSF）而非重组人白细胞介素3（rh-IL3）进行预处理，可增强血小板活化因子（PAF）诱导的豚鼠气道嗜酸性粒细胞聚集。
Br J Pharmacol. 1990 Jul;100(3):399-400. doi: 10.1111/j.1476-5381.1990.tb15817.x.
2
Eosinophil accumulation in pulmonary airways of guinea-pigs induced by exposure to an aerosol of platelet-activating factor: effect of anti-asthma drugs.血小板活化因子气雾剂暴露诱导豚鼠肺气道嗜酸性粒细胞积聚：抗哮喘药物的作用
Br J Pharmacol. 1990 Feb;99(2):267-72. doi: 10.1111/j.1476-5381.1990.tb14692.x.
3
Stimulation of human hematopoietic progenitor cell proliferation and differentiation by recombinant human interleukin 3. Comparison and interactions with recombinant human granulocyte-macrophage and granulocyte colony-stimulating factors.重组人白细胞介素3对人造血祖细胞增殖和分化的刺激作用。与重组人粒细胞-巨噬细胞集落刺激因子和粒细胞集落刺激因子的比较及相互作用。
Exp Hematol. 1989 Feb;17(2):191-7.
4
Effects of isozyme-selective phosphodiesterase inhibitors on eosinophil infiltration in the guinea-pig lung.同工酶选择性磷酸二酯酶抑制剂对豚鼠肺嗜酸性粒细胞浸润的影响。
Eur J Pharmacol. 1994 Apr 1;255(1-3):253-6. doi: 10.1016/0014-2999(94)90107-4.
5
Activity of a novel thienodiazepine derivative as a platelet-activating factor antagonist in guinea pig lungs. Effects on platelet-activating factor and allergen induced eosinophil accumulation.一种新型噻吩二氮卓衍生物在豚鼠肺中作为血小板活化因子拮抗剂的活性。对血小板活化因子和变应原诱导的嗜酸性粒细胞积聚的影响。
Arzneimittelforschung. 1991 Mar;41(3):224-7.
6
The effect of heparin and related proteoglycans on allergen and PAF-induced eosinophil infiltration.肝素及相关蛋白聚糖对变应原和血小板活化因子诱导的嗜酸性粒细胞浸润的影响。
J Lipid Mediat. 1993 Jul;7(3):269-78.
7
Inhibition of PAF-induced eosinophil accumulation in pulmonary airways of guinea pigs by anti-asthma drugs.抗哮喘药物对血小板活化因子诱导的豚鼠肺气道嗜酸性粒细胞聚集的抑制作用。
Jpn J Pharmacol. 1989 Oct;51(2):167-72. doi: 10.1254/jjp.51.167.
8
PAF-induced bronchial hyperresponsiveness in the rabbit: contribution of platelets and airway smooth muscle.血小板活化因子诱导的兔支气管高反应性：血小板和气道平滑肌的作用
Br J Pharmacol. 1990 Sep;101(1):31-8. doi: 10.1111/j.1476-5381.1990.tb12084.x.
9
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction.
J Investig Allergol Clin Immunol. 2003;13(2):79-86.
10
[Inhalation of platelet-activating factor induced guinea pig airway hyperresponsiveness: role of eosinophils activation].
Zhonghua Jie He He Hu Xi Za Zhi. 1995 Jun;18(3):155-7, 190.

引用本文的文献

1
Effect of murine recombinant interleukin-5 on the cell population in guinea-pig airways.小鼠重组白细胞介素-5对豚鼠气道细胞群的影响。
Br J Pharmacol. 1992 Jan;105(1):19-22. doi: 10.1111/j.1476-5381.1992.tb14204.x.
2
Production of granulocyte-macrophage colony-stimulating factor by cultured human tracheal epithelial cells.培养的人气管上皮细胞产生粒细胞巨噬细胞集落刺激因子。
Immunology. 1992 Jan;75(1):189-95.
3
Effect of human recombinant interleukin-5 on in vitro responsiveness to PAF of lung from actively sensitized guinea-pigs.人重组白细胞介素-5对主动致敏豚鼠肺组织体外对血小板活化因子反应性的影响。
Br J Pharmacol. 1992 Jul;106(3):677-84. doi: 10.1111/j.1476-5381.1992.tb14394.x.

本文引用的文献

1
The eosinophil and the pathophysiology of asthma.嗜酸性粒细胞与哮喘的病理生理学
J Allergy Clin Immunol. 1986 Apr;77(4):527-37. doi: 10.1016/0091-6749(86)90341-6.
2
Early and late-phase bronchoconstriction after allergen challenge of nonanesthetized guinea pigs. I. The association of disordered airway physiology to leukocyte infiltration.未麻醉豚鼠变应原激发后的早期和晚期支气管收缩。I. 气道生理紊乱与白细胞浸润的关联。
Am Rev Respir Dis. 1988 Mar;137(3):548-57. doi: 10.1164/ajrccm/137.3.548.
3
Skin eosinophilia in atopic patients.
J Allergy Clin Immunol. 1988 Apr;81(4):691-5. doi: 10.1016/0091-6749(88)91040-8.
4
Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists.血小板活化因子（PAF-乙酰醚）和变应原给药后嗜酸性粒细胞向豚鼠肺内的募集。前列环素、血小板耗竭及选择性拮抗剂的调节作用。
Am Rev Respir Dis. 1988 Apr;137(4):948-54. doi: 10.1164/ajrccm/137.4.948.
5
Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts.在3T3成纤维细胞存在的情况下，粒细胞/巨噬细胞集落刺激因子对人嗜酸性粒细胞活力、密度和功能的调节作用。
J Exp Med. 1987 Jul 1;166(1):129-41. doi: 10.1084/jem.166.1.129.
6
Deposits of eosinophil granule proteins in cardiac tissues of patients with eosinophilic endomyocardial disease.嗜酸性粒细胞性心内膜疾病患者心脏组织中嗜酸性粒细胞颗粒蛋白的沉积。
Lancet. 1987 Mar 21;1(8534):643-7. doi: 10.1016/s0140-6736(87)90412-0.
7
Leukotriene production in human neutrophils primed by recombinant human granulocyte/macrophage colony-stimulating factor and stimulated with the complement component C5A and FMLP as second signals.在重组人粒细胞/巨噬细胞集落刺激因子致敏并以补体成分C5A和FMLP作为第二信号刺激的人中性粒细胞中白三烯的产生。
J Exp Med. 1988 Apr 1;167(4):1281-95. doi: 10.1084/jem.167.4.1281.
8
Eosinophil accumulation in pulmonary airways of guinea-pigs induced by exposure to an aerosol of platelet-activating factor: effect of anti-asthma drugs.血小板活化因子气雾剂暴露诱导豚鼠肺气道嗜酸性粒细胞积聚：抗哮喘药物的作用
Br J Pharmacol. 1990 Feb;99(2):267-72. doi: 10.1111/j.1476-5381.1990.tb14692.x.

用重组人粒细胞巨噬细胞集落刺激因子（rh-GMCSF）而非重组人白细胞介素3（rh-IL3）进行预处理，可增强血小板活化因子（PAF）诱导的豚鼠气道嗜酸性粒细胞聚集。

Pretreatment with rh-GMCSF, but not rh-IL3, enhances PAF-induced eosinophil accumulation in guinea-pig airways.

作者信息

Sanjar S, Smith D, Kings M A, Morley J

机构信息

Preclincal Research, Sandoz Ltd., Basel, Switzerland.

出版信息

Br J Pharmacol. 1990 Jul;100(3):399-400. doi: 10.1111/j.1476-5381.1990.tb15817.x.

DOI:10.1111/j.1476-5381.1990.tb15817.x
PMID:2202477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1917787/
Abstract

Intraperitoneal injections of recombinant human granulocyte-macrophage colony stimulating factor (rh-GMCSF, 50 micrograms/kg-1 daily) or interleukin-3 (rh-IL3, 50 micrograms kg-1 daily) for two days, induced an increase in the percentage of bone marrow and pulmonary airway eosinophils in the guinea-pig. In addition, rh-IL3-treated animals exhibited an increase (21%) in blood neutrophils. Exposure of guinea-pigs to an aerosol of platelet activating factor (PAF) gives rise to a selective pulmonary eosinophil accumulation, maximal at 48 h. The eosinophilic response to PAF was significantly enhanced in rh-GMCSF-treated guinea-pigs but was suppressed in rh-IL3-treated animals.

摘要

腹腔注射重组人粒细胞巨噬细胞集落刺激因子（rh-GMCSF，每日50微克/千克）或白细胞介素-3（rh-IL3，每日50微克/千克），连续两天，可使豚鼠骨髓和肺气道嗜酸性粒细胞百分比增加。此外，经rh-IL3处理的动物血液中性粒细胞增加（21%）。豚鼠暴露于血小板活化因子（PAF）气雾剂中会导致选择性肺嗜酸性粒细胞积聚，在48小时时达到最大值。在经rh-GMCSF处理的豚鼠中，对PAF的嗜酸性粒细胞反应显著增强，但在经rh-IL3处理的动物中受到抑制。