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The absence of introns in yeast mitochondria does not abolish mitochondrial recombination.

作者信息

Boulet A, Levra-Juillet E, Perea J, Faye G

机构信息

Institut Curie-Biologie, Centre Universitaire, Orsay, France.

出版信息

Curr Genet. 1990 Jun;17(6):537-41. doi: 10.1007/BF00313085.

DOI:10.1007/BF00313085
PMID:2202528
Abstract

The respiratory competency of a yeast strain devoid of mitochondrial introns is quite normal. However, it may be asked whether intron-encoded proteins participate in metabolisms other than those of mitochondrial introns. Using strains without mitochondrial introns we have answered two questions. The first was: does the absence of intron-encoded proteins abolish mitochondrial recombination? The second was: do mitochondrial introns and intron-encoded proteins play a part in mitochondrial DNA rearrangements induced by ethidium bromide (rho- production)? We have shown that the introns and intron-encoded proteins are not essential components of either phenomenon.

摘要

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The biology of yeast mitochondrial introns.

本文引用的文献

1
The double-strand-break repair model for recombination.用于重组的双链断裂修复模型。
Cell. 1983 May;33(1):25-35. doi: 10.1016/0092-8674(83)90331-8.
2
Unequal excision of complementary strands is involved in the generation of palindromic repetitions of rho- mitochondrial DNA in yeast.互补链的不等切除参与了酵母中rho-线粒体DNA回文重复序列的产生。
Cell. 1983 Feb;32(2):391-6. doi: 10.1016/0092-8674(83)90458-0.
3
Ethidium bromide induced mutation of yeast mitochondria: complete transformation of cells into respiratory deficient non-chromosomal "petites".
酵母线粒体内含子的生物学特性。
Mol Biol Rep. 1993 Jun;18(1):1-13. doi: 10.1007/BF01006890.
4
The mitochondrial genome of fission yeast: inability of all introns to splice autocatalytically, and construction and characterization of an intronless genome.裂殖酵母的线粒体基因组:并非所有内含子都能进行自催化剪接,以及无内含子基因组的构建与表征
Mol Gen Genet. 1991 Jan;225(1):158-67. doi: 10.1007/BF00282654.
5
An endonuclease with multiple cutting sites, Endo.SceI, initiates genetic recombination at its cutting site in yeast mitochondria.一种具有多个切割位点的核酸内切酶,即I-SceI内切酶,可在酵母线粒体的切割位点引发基因重组。
EMBO J. 1992 Jul;11(7):2707-15. doi: 10.1002/j.1460-2075.1992.tb05336.x.
溴化乙锭诱导酵母线粒体突变:细胞完全转变为呼吸缺陷型非染色体“小菌落”。
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4
Mitochondrial genetics IX: A model for recombination and segregation of mitochondrial genomes in saccharomyces cerevisiae.线粒体遗传学IX:酿酒酵母中线粒体基因组重组与分离的模型
Genetics. 1974 Sep;78(1):415-37. doi: 10.1093/genetics/78.1.415.
5
Mitochondrial genetics. IV. Allelism and mapping studies of oligomycin resistant mutants in S. cerevisiae.线粒体遗传学。IV. 酿酒酵母中寡霉素抗性突变体的等位性和图谱研究。
Mol Gen Genet. 1973 Sep 5;125(1):9-52. doi: 10.1007/BF00292982.
6
Extrachromosomal inheritance of paromomycin resistance in Saccharomyces cerevisiae. Genetic and biochemical characterization of mutants.酿酒酵母中对巴龙霉素抗性的染色体外遗传。突变体的遗传和生化特征
Mol Gen Genet. 1973 Sep 5;125(1):91-8. doi: 10.1007/BF00292984.
7
Mitochondrial nucleic acids in the petite colonie mutants: deletions and repetition of genes.小菌落突变体中的线粒体核酸:基因缺失与重复
Biochimie. 1973;55(6):779-92. doi: 10.1016/s0300-9084(73)80030-6.
8
Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA.将线粒体注入人类细胞会导致内源性线粒体DNA迅速被取代。
Cell. 1988 Mar 25;52(6):811-9. doi: 10.1016/0092-8674(88)90423-0.
9
Construction of a yeast strain devoid of mitochondrial introns and its use to screen nuclear genes involved in mitochondrial splicing.构建不含线粒体内含子的酵母菌株及其用于筛选参与线粒体剪接的核基因的用途。
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6810-4. doi: 10.1073/pnas.84.19.6810.
10
Absence of extensive recombination between inter- and intraspecies mitochondrial DNA in mammalian cells.哺乳动物细胞种间和种内线粒体DNA之间不存在广泛重组。
Exp Cell Res. 1985 Oct;160(2):387-95. doi: 10.1016/0014-4827(85)90185-5.