奥比宁B：一种来自格孢腔菌目的未鉴定真菌（MSX 63619）的邻吡喃萘醌十肽。
Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.
作者信息
Ayers Sloan, Graf Tyler N, Adcock Audrey F, Kroll David J, Shen Qi, Swanson Steven M, Wani Mansukh C, Darveaux Blaise A, Pearce Cedric J, Oberlies Nicholas H
机构信息
University of North Carolina at Greensboro, Department of Chemistry and Biochemistry, P.O. Box 26170, Greensboro, NC 27402.
出版信息
Tetrahedron Lett. 2011 Oct 5;52(40):5128-5230. doi: 10.1016/j.tetlet.2011.07.102.
Abstract
A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC(50) value of 1 was moderate, ranging from 3 to 13 μM, depending on the cell line tested.
摘要
从拥有超过50000种真菌的Mycosynthetix文库中提取的一种真菌提取物（MSX 63619），对一组人类肿瘤细胞显示出有前景的细胞毒性。通过生物活性导向分级分离，分离出一种邻吡喃萘醌十肽，我们将其命名为obionin B（1）。通过光谱和质谱技术推导得出1的结构。1的半数抑制浓度（IC50）值适中，根据所测试的细胞系不同，范围在3至13μM之间。
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