Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, United States.
J Nat Prod. 2011 Oct 28;74(10):2137-42. doi: 10.1021/np2004243. Epub 2011 Oct 6.
Two new cyclodepsipeptides (1 and 2), two new sesquiterpenoids (3 and 4), and the known compounds guangomide A (5), roseotoxin S, and three simple trichothecenes were isolated from the cytotoxic organic extract of a terrestrial filamentous fungus, Trichothecium sp. The structures were determined using NMR spectroscopy and mass spectrometry. Absolute configurations of the cyclodepsipeptides were established by employing chiral HPLC, while the relative configurations of 3 and 4 were determined via NOESY data. The isolation of guangomide A was of particular interest, since it was reported previously from a marine-derived fungus.
从一株陆生丝状真菌( Trichothecium sp.)的细胞毒有机提取物中分离得到了两种新的环二肽(1 和 2)、两种新的倍半萜(3 和 4)以及已知化合物广构胺 A(5)、玫瑰菌素 S 和三种简单的曲霉菌。通过 NMR 光谱和质谱确定了结构。通过手性 HPLC 确定了环二肽的绝对构型,而通过 NOESY 数据确定了 3 和 4 的相对构型。广构胺 A 的分离特别有趣,因为它之前是从海洋来源的真菌中报道的。