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急性白血病和骨髓增生异常综合征中的血小板功能障碍。

Platelet dysfunction in acute leukemias and myelodysplastic syndromes.

作者信息

Vlădăreanu Ana Maria, Vasilache Veronica, Bumbea H, Onisâi Minodora

出版信息

Rom J Intern Med. 2011;49(1):93-6.

PMID:22026258
Abstract

The hemorrhagic and thrombotic diathesis represents a frequent complication in myelodysplastic syndromes (MDS) and in acute leukemias. They are correlated with the number of the platelets, but also with their qualitative disorders, such as membrane glycoprotein changes. The latter are revealed by many platelet studies including flow-cytometry and comprise modified activation, secretion and aggregation patterns.

摘要

出血和血栓形成素质是骨髓增生异常综合征(MDS)和急性白血病中常见的并发症。它们与血小板数量相关,但也与血小板的质量异常有关,如膜糖蛋白变化。后者通过包括流式细胞术在内的许多血小板研究得以揭示,包括活化、分泌和聚集模式的改变。

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Platelet dysfunction in acute leukemias and myelodysplastic syndromes.急性白血病和骨髓增生异常综合征中的血小板功能障碍。
Rom J Intern Med. 2011;49(1):93-6.
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An update on the platelet dysfunction in chronic myeloproliferative syndromes.慢性骨髓增殖性综合征中血小板功能障碍的最新进展。
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Bernard-Soulier-like functional platelet defect in myelodysplastic syndrome and in acute myeloblastic leukemia associated with trilineage myelodysplasia.骨髓增生异常综合征及与三系骨髓发育异常相关的急性髓细胞白血病中的类Bernard-Soulier功能性血小板缺陷。
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Flow Cytometry Protocols for Assessment of Platelet Function in Whole Blood.全血中血小板功能评估的流式细胞术方案
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Platelet counts and haemorrhagic diathesis in patients with myelodysplastic syndromes.骨髓增生异常综合征患者的血小板计数与出血素质
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[Pathogenesis of thrombotic and hemorrhagic complications in myeloproliferative and myelodysplastic syndromes].[骨髓增殖性和骨髓增生异常综合征中血栓形成和出血并发症的发病机制]
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Hemorrhagic risk due to platelet dysfunction in myelodysplastic patients, correlations with anemia severity and iron overload.骨髓增生异常患者血小板功能障碍所致出血风险,与贫血严重程度及铁过载的相关性。
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Platelet function in the myelodysplastic syndromes.骨髓增生异常综合征中的血小板功能
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