Janka H U
Krankenhaus München-Schwabing, Germany.
Horm Metab Res Suppl. 1990;22:8-11.
Cardiovascular diseases are the major cause of morbidity and mortality in the diabetic patient. The acceleration of atherogenesis occurs in all types of diabetes and culminates in such fatal complications as myocardial infarction, stroke and gangrene. Subjects with non-insulin-dependent diabetes mellitus exhibit a 3-4 times higher rate of cardiovascular mortality than non-diabetic persons. Since it was not possible to explain the excess risk by the traditional cardiovascular risk factors, various hypothesis have been put forward. These include certain aspects of blood pressure elevation, lipid changes, hyperinsulinemia, abnormal hemostasis, and impaired kidney function.
心血管疾病是糖尿病患者发病和死亡的主要原因。动脉粥样硬化的加速在所有类型的糖尿病中都会发生，并最终导致心肌梗死、中风和坏疽等致命并发症。非胰岛素依赖型糖尿病患者的心血管死亡率比非糖尿病患者高3至4倍。由于无法用传统的心血管危险因素来解释这种额外的风险，人们提出了各种假说。这些假说包括血压升高、血脂变化、高胰岛素血症、止血异常和肾功能受损等方面。
