1型糖尿病闭环控制实施中的临床障碍及可能的解决方案
Clinical hurdles and possible solutions in the implementation of closed-loop control in type 1 diabetes mellitus.
作者信息
Zisser Howard
机构信息
Sansum Diabetes Research Institute, University of California, Santa Barbara, Chemical Engineering, Santa Barbara, California 93105, USA.
出版信息
J Diabetes Sci Technol. 2011 Sep 1;5(5):1283-6. doi: 10.1177/193229681100500537.
Abstract
From an engineering perspective, controlling blood glucose appears to be a fairly straightforward single input (glucose), single output (insulin) control problem. Unfortunately, mimicking Mother Nature turns out to be a complex endeavor. The primary hurdle in developing a useful, safe closed-loop control algorithm for an artificial pancreas is the time delays associated with current continuous glucose monitors and subcutaneously delivered insulins. This article will provide a brief history of the artificial pancreas, outline the main clinical hurdles restricting its current implementation, and list possible solutions for success.
摘要
从工程学角度来看，控制血糖似乎是一个相当简单的单输入（葡萄糖）、单输出（胰岛素）控制问题。不幸的是，模仿大自然却被证明是一项复杂的工作。为人工胰腺开发一种有用、安全的闭环控制算法的主要障碍是当前连续血糖监测仪和皮下注射胰岛素所带来的时间延迟。本文将简要介绍人工胰腺的历史，概述限制其当前应用的主要临床障碍，并列出可能取得成功的解决方案。
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Closed-loop insulin delivery using a subcutaneous glucose sensor and intraperitoneal insulin delivery: feasibility study testing a new model for the artificial pancreas.闭环胰岛素输送利用皮下葡萄糖传感器和腹腔内胰岛素输送：一种新型人工胰腺的可行性研究。
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A reduction in severe hypoglycaemia in type 1 diabetes in a randomized crossover study of continuous intraperitoneal compared with subcutaneous insulin infusion.一项随机交叉研究显示，与皮下胰岛素输注相比，连续腹腔内输注可降低 1 型糖尿病患者的严重低血糖风险。
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