Murthy M Bhanu
Department of Periodontics, Army College of Dental Sciences, Secunderabad, Andhra Pradesh, India.
J Indian Soc Periodontol. 2011 Jul;15(3):190-8. doi: 10.4103/0972-124X.85659.
Osteoimmunology is an emerging field of research dedicated to the relationship between the immune processes and the bone metabolism of various inflammatory bone diseases. The regulatory mechanisms governing the osteoclast and osteoblast are critical for understanding the health and disease of the skeletal system. These interactions are either by cell to cell contact or by the secretion of immune regulatory mediators like cytokines and chemokines by immune cells that are governed by the RANKL (TRANCE)-RANK- OPG axis. TRANCE-RANK signaling has served as a cornerstone of osteoimmunology research. There is increased recognition of the importance of the inflammatory and immune responses in the pathogenesis of periodontal disease. Thus, this field has provided a framework for studying the mechanisms underlying periodontal destruction. As bone homeostasis is mainly regulated by both the immune and endocrine systems, there emerged osteoimmunoendocrinology where adipokines take the lead. This review focuses on the underlying concepts of osteoimmunology, its relation to Periodontics.
骨免疫学是一个新兴的研究领域，致力于研究免疫过程与各种炎性骨病的骨代谢之间的关系。调节破骨细胞和成骨细胞的机制对于理解骨骼系统的健康和疾病至关重要。这些相互作用要么通过细胞间接触，要么通过免疫细胞分泌细胞因子和趋化因子等免疫调节介质来实现，而这些免疫调节介质受RANKL（TRANCE）-RANK-OPG轴调控。TRANCE-RANK信号传导一直是骨免疫学研究的基石。人们越来越认识到炎症和免疫反应在牙周病发病机制中的重要性。因此，该领域为研究牙周破坏的潜在机制提供了一个框架。由于骨稳态主要由免疫系统和内分泌系统共同调节，于是出现了以脂肪因子为主导的骨免疫内分泌学。本综述重点关注骨免疫学的基本概念及其与牙周病学的关系。
