骨免疫学：细胞因子与骨骼系统
Osteoimmunology: cytokines and the skeletal system.
作者信息
Lee Seoung-Hoon, Kim Tae-Soo, Choi Yongwon, Lorenzo Joseph
机构信息
The Department of Pathology and Laboratory Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
出版信息
BMB Rep. 2008 Jul 31;41(7):495-510. doi: 10.5483/bmbrep.2008.41.7.495.
Abstract
It has become clear that complex interactions underlie the relationship between the skeletal and immune systems. This is particularly true for the development of immune cells in the bone marrow as well as the functions of bone cells in skeletal homeostasis and pathologies. Because these two disciplines developed independently, investigators with an interest in either often do not fully appreciate the influence of the other system on the functions of the tissue that they are studying. With these issues in mind, this review will focus on several key areas that are mediated by crosstalk between the bone and immune systems. A more complete appreciation of the interactions between immune and bone cells should lead to better therapeutic strategies for diseases that affect either or both systems.
摘要
骨骼系统与免疫系统之间的关系显然是由复杂的相互作用构成的。这在骨髓中免疫细胞的发育以及骨骼稳态和病理状态下骨细胞的功能方面尤为如此。由于这两个学科是独立发展的，对其中任何一个感兴趣的研究人员往往并不完全了解另一个系统对他们所研究组织功能的影响。考虑到这些问题，本综述将聚焦于由骨骼系统与免疫系统之间的相互作用所介导的几个关键领域。对免疫细胞与骨细胞之间相互作用的更全面理解应该会为影响其中一个或两个系统的疾病带来更好的治疗策略。
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