Metelitsa V I, Filatova N P
Kardiologiia. 1990 May;30(5):8-14.
A comparative study was undertaken to examine the long-acting beta-blocker nadolol without intrinsic sympathomimetic activity and reference agents such as anapriline, a beta-blocker, hypothiazide, a diuretic, and pratsiol, a postsynaptic alpha-adrenoblocker in 361 patients with sustained arterial hypertension (diastolic blood pressure, 95 mm Hg or more) in the randomized groups. The therapy was started with monotherapy of one of these drugs; if ineffective, a combination of two or, if necessary, three agents of different groups was given. The patients' status was monitored at least once monthly for 6 months. Monotherapy with beta-blockers or pratsiol was found to be more effective than that with diuretics. Addition of the second agent was required by 48% of the patients, that of the third agent, by 13%. Nadolol in combination with diuretics and/or pratsiol showed the same effects as did anapriline. The agent possessed a more pronounced negative chronotropic action than did anapriline when it was given alone or in combination. Nadolol caused a decrease in middle and small-sized bronchial patency as did anapriline. A 6-month nadolol therapy resulted in regression of left ventricular hypertrophy.
进行了一项比较研究，在361例持续性动脉高血压（舒张压95毫米汞柱或更高）患者的随机分组中，考察无内在拟交感活性的长效β受体阻滞剂纳多洛尔以及对照药物，如β受体阻滞剂阿那普利林、利尿剂氢氯噻嗪和突触后α肾上腺素能阻滞剂普拉西奥。治疗从使用这些药物之一进行单一疗法开始；如果无效，则给予两种药物的联合治疗，必要时给予三种不同组别的药物联合治疗。对患者的状况至少每月监测一次，持续6个月。发现使用β受体阻滞剂或普拉西奥进行单一疗法比使用利尿剂更有效。48%的患者需要添加第二种药物，13%的患者需要添加第三种药物。纳多洛尔与利尿剂和/或普拉西奥联合使用时显示出与阿那普利林相同的效果。单独给药或联合给药时，该药物比阿那普利林具有更明显的负性变时作用。纳多洛尔与阿那普利林一样，会导致中小支气管通畅性降低。为期6个月的纳多洛尔治疗导致左心室肥厚消退。
