[The comparative results of a short course of nadolol and propranolol treatment of arterial hypertension patients (cooperative research). The Working Group of the Cooperative Program for the Study of New Preparations in Preventing Arterial Hypertension].

The short-term continuous treatment with propranolol and nadolol, a long-acting nonselective beta-adrenoblocker without own sympathomimetic activity, conducted in two randomized groups of men with stable arterial hypertension (the diastolic AP greater than or equal to 95 mm Hg) has shown that by its hypotensive and negative chronotropic effects nadolol given in the mean dose 87 mg/day compared very favourably with propranolol administered in a dose of 144 mg/day. At the same time nadolol is more fit for patients since it may be taken once a day. The influence of both beta-blockers on the hemodynamic, metabolic parameters and external respiratory function was similar. Nadolol in doses of less than 200 mg/day did not lower the rate of glomerular filtration. On the use of the drug in doses of 240 and 280 mg/day the rate of glomerular filtration slightly decreased.