Chauhan Sarika Singh, Sarkar Purnima Dey, Bhimte Bhawna
Department of Biochemistry, Mahatma Gandhi Medical College, Indore, India.
Biochem Res Int. 2011;2011:740370. doi: 10.1155/2011/740370. Epub 2011 Oct 18.
Preterm is defined as a baby with a gestation of less than 37 completed weeks. In this study, serum calcium, phosphorus, ALP, creatinine, and electrolytes were measured in preterm babies. The present study comprised of 75 preterm babies of which 25 were of 28-30 weeks, 25 were of 30-32 weeks, and remaining 25 were of 34-36 weeks (controls) of gestational age. Serum calcium and phosphorus levels were found to be significantly decreased, and serum ALP, creatinine, and electrolytes were found to be significantly increased (P < 0.001) at 28-30 weeks as compared to controls, but serum calcium and phosphorous levels were found to be insignificantly decreased, whereas serum ALP activities were found to be insignificantly increased at 28-30 weeks as compared to 30-32 weeks of gestational age in preterm babies. It can be concluded that high serum ALP activity and low serum calcium and phosphorus levels are associated with preterm babies. A significant difference in the mean values of these renal function parameters was also obtained, except for serum sodium and potassium.
早产被定义为孕周不足37周的婴儿。在本研究中，对早产婴儿的血清钙、磷、碱性磷酸酶（ALP）、肌酐和电解质进行了测量。本研究包括75名早产婴儿，其中25名孕周为28 - 30周，25名孕周为30 - 32周，其余25名孕周为34 - 36周（作为对照）。与对照组相比，28 - 30周时血清钙和磷水平显著降低，血清ALP、肌酐和电解质显著升高（P < 0.001），但与孕周为30 - 32周的早产婴儿相比，28 - 30周时血清钙和磷水平降低不显著，而血清ALP活性升高不显著。可以得出结论，血清ALP活性升高以及血清钙和磷水平降低与早产婴儿有关。除血清钠和钾外，这些肾功能参数的平均值也存在显著差异。
