Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, SE-90185 Umeå, Sweden.
Parkinsons Dis. 2011;2011:658956. doi: 10.4061/2011/658956. Epub 2011 Oct 19.
Deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson's disease (PD) affects speech inconsistently. Recently, stimulation of the caudal zona incerta (cZi-DBS) has shown superior motor outcomes for PD patients, but effects on speech have not been systematically investigated. The aim of this study was to compare the effects of cZi-DBS and STN-DBS on voice intensity in PD patients. Mean intensity during reading and intensity decay during rapid syllable repetition were measured for STN-DBS and cZi-DBS patients (eight patients per group), before- and 12 months after-surgery on- and off-stimulation. For mean intensity, there were small significant differences on- versus off-stimulation in each group: 74.2 (2.0) dB contra 72.1 (2.2) dB (P = .002) for STN-DBS, and 71.6 (4.1) dB contra 72.8 (3.4) dB (P = .03) for cZi-DBS, with significant interaction (P < .001). Intensity decay showed no significant changes. The subtle differences found for mean intensity suggest that STN-DBS and cZi-DBS may influence voice intensity differently.
丘脑底核（STN-DBS）深部脑刺激对帕金森病（PD）患者的语音影响不一致。最近，尾状核下区（cZi-DBS）的刺激对 PD 患者的运动功能有更好的效果，但对语音的影响尚未系统研究。本研究旨在比较 cZi-DBS 和 STN-DBS 对 PD 患者语音强度的影响。在手术前和手术后 12 个月，对 STN-DBS 和 cZi-DBS 患者（每组 8 例）进行阅读时的平均强度和快速音节重复时的强度衰减测量，分别在刺激开启和关闭时进行。对于平均强度，在每组中，刺激开启与关闭时存在微小但显著的差异：STN-DBS 为 74.2（2.0）dB 对 72.1（2.2）dB（P =.002），cZi-DBS 为 71.6（4.1）dB 对 72.8（3.4）dB（P =.03），具有显著的交互作用（P <.001）。强度衰减没有明显变化。对于平均强度，发现的细微差异表明 STN-DBS 和 cZi-DBS 可能以不同的方式影响语音强度。
