Departments of Vascular Biology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan.
Pathol Int. 2011 Nov;61(11):630-7. doi: 10.1111/j.1440-1827.2011.02726.x. Epub 2011 Oct 10.
Tumor blood vessels play an important role in tumor progression and metastasis. Thus, targeting the tumor blood vessels is an important strategy in cancer therapy. Tumor blood vessels generally arise from pre-existing vessels and have been thought to be genetically normal. However, they have been shown to differ from their normal counterparts, e.g. with regard to the morphological changes. We isolated tumor endothelial cells (TEC) from mouse tumor xenografts and showed that they were abnormal. TEC up-regulate many genes, proliferate more rapidly and migrate more than normal endothelial cells (NEC). Furthermore, the TEC in our study were cytogenetically abnormal. We concluded that TEC can acquire cytogenetic abnormalities while in the tumor microenvironment. In order to develop ideal antiangiogenic therapies, understanding the crosstalk between blood vessels and the tumor microenvironment is important. This review considers the current studies on TEC abnormalities and discusses the possible mechanism by which the tumor microenvironment produces abnormal TEC.
肿瘤血管在肿瘤的进展和转移中起着重要作用。因此，针对肿瘤血管是癌症治疗的一个重要策略。肿瘤血管通常起源于预先存在的血管，并且被认为是遗传正常的。然而，它们已经被证明与正常血管不同，例如在形态学变化方面。我们从小鼠肿瘤异种移植物中分离出肿瘤内皮细胞（TEC），并表明它们是异常的。TEC 上调许多基因，比正常内皮细胞（NEC）增殖更快，迁移更多。此外，我们研究中的 TEC 在细胞遗传学上是异常的。我们得出结论，TEC 可以在肿瘤微环境中获得细胞遗传学异常。为了开发理想的抗血管生成疗法，了解血管和肿瘤微环境之间的相互作用非常重要。这篇综述考虑了目前关于 TEC 异常的研究，并讨论了肿瘤微环境产生异常 TEC 的可能机制。
