老年患者中肺炎衣原体相关急性缺血性卒中的结局：一项病例对照研究。
Outcome of Chlamydia pneumoniae associated acute ischemic stroke in elderly patients: a case-control study.
作者信息
Bandaru V C S Srinivasarao, Boddu Demudu Babu, Mridula K Rukmini, Akhila B, Alladi Suvarna, Laxmi V, Pathapati Rammohan, Neeraja M, Kaul Subhash
机构信息
Department of Clinical Research, Yashoda Hospital, Somajiguda, Hyderabad 500082, India.
出版信息
Clin Neurol Neurosurg. 2012 Feb;114(2):120-3. doi: 10.1016/j.clineuro.2011.09.016. Epub 2011 Oct 24.
BACKGROUND
Limited data exists about the role of Chlamydia pneumoniae elderly patients with acute ischemic stroke.
OBJECTIVE
To study the role of C. pneumoniae in elderly patients (age more than 65 years) with acute ischemic stroke and its impact on stroke out come.
METHODS
We recruited 100 elderly patients with acute ischemic stroke and 100 age and sex matched controls over a period of 2 years. IgG and IgA anti C. pneumoniae antibodies were measured by microimmunofluorescence technique in patients and controls. Good outcome was defined as a Modified Rankin score (mRS) of ≤2.
RESULTS
We found C. pneumoniae antibodies in 35% stroke patients and in 18% control subjects (p=0.01). Good out come at 90 days follow up was found in 20/35(57.1%) seropositive stroke patients compared to 37/65(56.9%) seronegative stroke patients (p=0.9).
CONCLUSIONS
C. pneumoniae antibody positivity was independently associated with ischemic stroke in elderly patients and its presence does not alter the stroke outcome.
背景
关于肺炎衣原体在老年急性缺血性脑卒中患者中的作用，现有数据有限。
目的
研究肺炎衣原体在老年（年龄大于65岁）急性缺血性脑卒中患者中的作用及其对脑卒中结局的影响。
方法
在2年的时间里，我们招募了100例老年急性缺血性脑卒中患者和100例年龄及性别匹配的对照。采用微量免疫荧光技术检测患者和对照中抗肺炎衣原体IgG和IgA抗体。良好结局定义为改良Rankin量表（mRS）评分≤2。
结果
我们在35%的脑卒中患者和18%的对照受试者中发现了肺炎衣原体抗体（p=0.01）。在90天随访时，20/35（57.1%）血清阳性的脑卒中患者结局良好，而血清阴性的脑卒中患者为37/65（56.9%）（p=0.9）。
结论
肺炎衣原体抗体阳性与老年患者缺血性脑卒中独立相关，其存在并未改变脑卒中结局。
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