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[坏疽性脓皮病与白塞病:两例儿科病例研究]

[Pyoderma gangrenosum and Behçet's disease: a study of two pediatric cases].

作者信息

Hali F, Khadir K, Chiheb S, Bouayad K, Mikou N, Benchikhi H

机构信息

Service de dermatologie vénéréologie, centre hospitalier Ibn Rochd, Casablanca, Maroc.

出版信息

Arch Pediatr. 2011 Dec;18(12):1320-3. doi: 10.1016/j.arcped.2011.09.007. Epub 2011 Oct 24.

DOI:10.1016/j.arcped.2011.09.007
PMID:22030347
Abstract

Pyoderma gangrenosum is a rare neutrophilic dermatosis that affects 4% of children. It is characterized by its association in half of the cases with an underlying disease. The association with Behçet's disease is exceptional and may have a very poor prognosis. We report 2 pediatric observations with fatal outcome.

摘要

坏疽性脓皮病是一种罕见的嗜中性皮病,影响4%的儿童。其特点是半数病例与潜在疾病有关。与白塞病的关联极为罕见,且预后可能很差。我们报告2例儿科病例,均为致命结局。

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1
[Pyoderma gangrenosum and Behçet's disease: a study of two pediatric cases].[坏疽性脓皮病与白塞病:两例儿科病例研究]
Arch Pediatr. 2011 Dec;18(12):1320-3. doi: 10.1016/j.arcped.2011.09.007. Epub 2011 Oct 24.
2
Vegetative pyoderma gangrenosum in Behçet's disease.白塞病中的增殖性坏疽性脓皮病。
Acta Derm Venereol. 2007;87(4):365-7. doi: 10.2340/00015555-0221.
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Accelerated healing of pyoderma gangrenosum in Behçet patient treated with cyclosporine and split thickness skin graft.用环孢素和中厚皮片移植治疗的白塞病患者坏疽性脓皮病加速愈合
Ann Plast Surg. 2008 Nov;61(5):552-4. doi: 10.1097/SAP.0b013e31816dd391.
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Intestinal Behçet's disease with pyoderma gangrenosum successfully treated with the combination therapy of adalimumab and glucocorticoids.阿达木单抗与糖皮质激素联合治疗成功治愈伴有坏疽性脓皮病的肠道白塞病。
Mod Rheumatol. 2018 Sep;28(5):901-905. doi: 10.3109/14397595.2016.1174327. Epub 2016 May 4.
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[Pyoderma gangrenosum. 15 cases].[坏疽性脓皮病。15例]
Ann Med Interne (Paris). 2001 Feb;152(1):3-9.
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[Pyoderma gangrenosum in an infant: Case report].[婴儿坏疽性脓皮病:病例报告]
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Pyoderma gangrenosum associated with Behçet's syndrome--response to thalidomide.与白塞病相关的坏疽性脓皮病——对沙利度胺的反应
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[Aseptic adenitis in pyoderma gangrenosum].[坏疽性脓皮病中的无菌性腺炎]
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Cutaneous manifestations of systemic disease: sarcoidosis, GVHD, Behcet's disease, and pyoderma gangrenosum.全身性疾病的皮肤表现:结节病、移植物抗宿主病、白塞病和坏疽性脓皮病。
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Idiopathic pyoderma gangrenosum: successful resolution with infliximab therapy and pro-inflammatory cytokines assessment.特发性坏疽性脓皮病:英夫利昔单抗治疗成功缓解及促炎细胞因子评估
Acta Derm Venereol. 2012 Jul;92(4):439-40. doi: 10.2340/00015555-1301.

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T helper type 1-related molecules as well as interleukin-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum.1型辅助性T细胞相关分子以及白细胞介素-15在坏疽性脓皮病患者的皮肤病变中高度表达。
Clin Exp Immunol. 2017 Sep;189(3):383-391. doi: 10.1111/cei.12989. Epub 2017 Jun 23.