Lotz-Winter H
Planta Med. 1990 Jun;56(3):249-53. doi: 10.1055/s-2006-960949.
Bromelain, a standardized complex of proteases from the pineapple plant, is absorbed unchanged from the intestine of animals at a rate of 40%; in animal experiments it was found to have primarily anti-edema, antiinflammatory, and coagulation-inhibiting effects. These effects are due to an enhancement of the serum fibrinolytic activity and inhibition of the fibrinogen synthesis, as well as a direct degradation of fibrin and fibrinogen. Bromelain lowers kininogen and bradykinin serum and tissue levels and has an influence on prostaglandin synthesis, thus acting antiinflammatory. In in vitro and in animal studies, experimentally induced tumours could be inhibited by bromelain. Although many studies do not give extensive statistical data, the effects of bromelain in animal studies seem to be dose-dependent. Further investigations have to be carried out.
菠萝蛋白酶是一种从菠萝植物中提取的标准化蛋白酶复合物，它能以40%的吸收率完整地从动物肠道吸收；在动物实验中发现它主要具有抗水肿、抗炎和抑制凝血的作用。这些作用归因于血清纤维蛋白溶解活性的增强、纤维蛋白原合成的抑制，以及纤维蛋白和纤维蛋白原的直接降解。菠萝蛋白酶可降低激肽原和缓激肽的血清及组织水平，并对前列腺素合成产生影响，从而发挥抗炎作用。在体外和动物研究中，菠萝蛋白酶可抑制实验诱导的肿瘤。尽管许多研究未给出广泛的统计数据，但菠萝蛋白酶在动物研究中的作用似乎呈剂量依赖性。还需进一步开展研究。
