Department of Pathology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, USA.
Am J Clin Pathol. 2011 Nov;136(5):762-6. doi: 10.1309/AJCPXNUC7JZSKWEU.
p63 is a p53 homolog that is expressed in various normal epithelial tissues and epithelial malignancies. Its expression in mesenchymal lesions has not been examined in depth; therefore, we studied p63 expression by immunohistochemical analysis in 650 soft tissue tumors. We found that p63 expression is limited in soft tissue tumors. The majority of tumors studied were p63-, including all cases of angiosarcoma, lipomatous neoplasms, dermatofibrosarcoma protuberans, solitary fibrous tumor, schwannoma, neurofibroma, gastrointestinal stromal tumor, and leiomyosarcoma. Nuclear p63 reactivity was found in a subset of soft tissue myoepithelioma and myoepithelial carcinoma of soft tissue, cellular neurothekeoma, soft tissue perineurioma, Ewing sarcoma/peripheral neuroectodermal tumor, diffuse-type giant cell tumor, and giant cell tumor of soft parts. Infrequent, weak, or focal p63-staining patterns were observed in low-grade fibromyxoid sarcoma, malignant peripheral nerve sheath tumor, extraskeletal myxoid chondrosarcoma, myxofibrosarcoma, proximal-type epithelioid sarcoma, synovial sarcoma, embryonal rhabdomyosarcoma, desmoplastic small round cell tumor, atypical fibroxanthoma, and spindle cell melanoma. Absent p63 expression is typical for most soft tissue tumors, including most (but not all) that would be in the differential diagnosis of spindle cell squamous carcinoma.
p63 是一种与 p53 同源的蛋白，在各种正常上皮组织和上皮恶性肿瘤中表达。其在间叶性病变中的表达尚未被深入研究；因此，我们通过免疫组织化学分析研究了 650 例软组织肿瘤中 p63 的表达。我们发现 p63 的表达在软组织肿瘤中受到限制。研究的大多数肿瘤均为 p63-，包括所有的血管肉瘤、脂肪性肿瘤、隆突性皮肤纤维肉瘤、孤立性纤维性肿瘤、神经鞘瘤、神经纤维瘤、胃肠道间质瘤和平滑肌肉瘤。在软组织肌上皮瘤和软组织肌上皮癌、细胞性神经鞘瘤、软组织神经鞘瘤、尤文肉瘤/外周神经外胚层肿瘤、弥漫性巨细胞瘤和软组织巨细胞瘤的一部分中发现了核 p63 反应性。在低级别纤维黏液样肉瘤、恶性外周神经鞘瘤、骨外黏液样软骨肉瘤、黏液纤维肉瘤、近端型上皮样肉瘤、滑膜肉瘤、胚胎性横纹肌肉瘤、促结缔组织增生性小圆细胞肿瘤、非典型性纤维黄色瘤和梭形细胞黑色素瘤中观察到罕见、微弱或局灶性的 p63 染色模式。大多数软组织肿瘤缺乏 p63 表达，包括大多数（但并非全部）在鉴别诊断中需要与梭形细胞鳞状细胞癌相鉴别的肿瘤。
