Dept of Pathology, 1950 Circle of Hope, Salt Lake City, UT 84112, USA.
Am J Clin Pathol. 2011 Nov;136(5):767-72. doi: 10.1309/AJCP4FFSBPHAU8IU.
"Floaters" represent a potential cause of diagnostic error and may arise during tissue processing and slide preparation. Our objective was to determine the frequency of floaters in slides and features useful in their recognition. We reviewed quality assurance (QA) records for floaters in slides and prospectively examined 1,000 additional slides for floaters and documented floater size, location, and presence in 1 or more sections. In the 521,661 slides reviewed for QA, 65 floaters were detected: 28 were present in the tissue block, and 37 were found only in a single level. In the 1,000 prospectively examined slides, 12 floaters were detected; 9 were only in a single section. Floaters represent a potential source of diagnostic error and occur in 0.01% to 1.2% of slides. Pick up of floaters from the water bath appears most common (∼60%). Floaters in only 1 level and mismatch with the specimen tissue type are clues to the extraneous nature of the floater.
“浮游物”是诊断错误的潜在原因之一，可能在组织处理和载玻片准备过程中出现。我们的目的是确定浮游物在载玻片上的出现频率以及识别浮游物时有用的特征。我们回顾了载玻片上浮游物的质量保证（QA）记录，并前瞻性地检查了 1000 张额外的载玻片是否存在浮游物，并记录了浮游物的大小、位置以及是否在 1 个或多个切片中存在。在审查的 521661 张 QA 载玻片上，发现了 65 个浮游物：28 个存在于组织块中，37 个仅在单个切片中发现。在前瞻性检查的 1000 张载玻片上，发现了 12 个浮游物；9 个仅在单个切片中发现。浮游物是诊断错误的潜在来源，在 0.01%至 1.2%的载玻片上出现。从水槽中拾起浮游物似乎最为常见（约 60%）。仅在 1 个切片中发现且与标本组织类型不匹配是浮游物为外来物的线索。
